By performing ¹⁵N pulse-labeling of mice, the turnover of hundreds of proteins in eye tissues was measured by mass spectrometry that revealed long-lived metabolic enzymes in the lens.

Exceptionally long-lived macromolecules in mammalian ovaries and oocytes serve as pillars for lifelong reproductive health span.

The yeast U1 snRNP recognizes multiple features of target RNAs to reversibly identify splicing-competent 5' splice sites.

Cancer control, DNA repair, and immunity are key functionalities underlying the evolution of extended lifespan in mammals.

Enigmatic long-lived plasma cells display an enhanced clustering in bone marrow niches and require CXCR4 for retention, survival, and maintenance of antibody titers.

A simple and effective method facilitates the study of in vivo transcriptional dynamics using transcriptional enhancers and destabilized fluorescent protein, which is suitable for both live imaging and fixed studies.

Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.

Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.

Multi-omic profiling of gene expression in response to reduced insulin/IGF-like-signalling reveals tissue-specific regulation of DNA damage and lysosomal mannosidase regulation of tissue homeostasis as pro-longevity responses.

Knockoff is a tool for researchers who wish to acutely disrupt a membrane protein.