Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.

Surface plasmon resonance studies reveal that clustered protocadherins have precisely tuned trans homophilic binding interactions and promiscuous but variable cis interactions, consistent with the requirement of forming error-free linear molecular zippers used by mammalian neurons to distinguish self from nonself.

Localized drug photoactivation provides light-mediated analgesia in behaving mice.

A real-time, stopped-flow method, in combination with protein-induced fluorescence enhancement, Förster resonance energy transfer, and time-resolved fluorescence spectroscopy, reveals a kinetic framework for understanding Dicer as a complex molecular motor.

Discussions about biological individuality and immunogenicity continue the long history of dialogue between philosophers and immunologists.

The scanning-assisted clustering mechanism of IFI16 not only allows efficient assembly on exposed foreign-dsDNA, but also suppresses the engagement of chromatinized self-dsDNA.

Virus infection in mosquitoes initiates a highly discriminatory process in which fragments of viral RNA are reverse transcribed to create DNA copies that serve as templates of small antiviral RNAs.

Rat behavior and dopamine release are preferentially modulated by subjective rather than objective evaluation of outcomes in a social setting.