531 results found
    1. Computational and Systems Biology
    2. Neuroscience

    A simple generative model of the mouse mesoscale connectome

    Sid Henriksen, Rich Pang, Mark Wronkiewicz
    A realistic model of the connections between local populations of neurons in the adult mouse brain can be constructed based on just two biologically plausible rules.
    1. Evolutionary Biology

    A non-archaeopterygid avialan theropod from the Late Jurassic of southern Germany

    Oliver WM Rauhut, Helmut Tischlinger, Christian Foth
    A new taxon from the Late Jurassic of southern Germany represents the second volant bird known from that time period and documents the improvement of flapping flight in bird evolution.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of Stu2 recruitment to yeast kinetochores

    Jacob A Zahm, Michael G Stewart ... Matthew P Miller
    The results here show that Stu2 binds kinetochores by associating with the Ndc80 complex and that the interaction is critical for accurate chromosome segregation during cell division.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Influenza A virus surface proteins are organized to help penetrate host mucus

    Michael D Vahey, Daniel A Fletcher
    By distributing receptor-binding and receptor-destroying proteins asymmetrically on their surface, filamentous influenza A virus particles create a Brownian ratchet that facilitates their passage through mucus.
    1. Cell Biology

    Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation

    Duccio Conti, Parveen Gul ... Viji M Draviam
    Human chromosome-microtubule attachments are stabilised by Astrin-mediated dynamic delivery of PP1 phosphatase to the attachment site, which ensures the normal segregation of chromosomes.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tissue-autonomous immune response regulates stress signaling during hypertrophy

    Robert Krautz, Dilan Khalili, Ulrich Theopold
    The immune effector Drosomycin buffers stress signaling in hypertrophic salivary glands to inhibit their disintegration, detection by the cellular immune response, and promotes further overgrowth.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

    Agata P Zielinska, Zuzana Holubcova ... Melina Schuh
    Multiple age-related changes in chromosome architecture could explain why human oocyte aneuploidy increases with advanced maternal age.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The COMA complex interacts with Cse4 and positions Sli15/Ipl1 at the budding yeast inner kinetochore

    Josef Fischböck-Halwachs, Sylvia Singh ... Franz Herzog
    The chromosomal passenger complex interacts with the inner kinetochore COMA complex through the Ctf19 C-terminus in vitro which is shown to be important for mediating accurate chromosome segregation.
    1. Neuroscience

    The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion

    Peter Soba, Chun Han ... Yuh Nung Jan
    A cell surface receptor called Ret enables neurons to establish and maintain the organized arrays of dendrites that support communication between neurons.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Global chromatin mobility induced by a DSB is dictated by chromosomal conformation and defines the HR outcome

    Fabiola García Fernández, Etienne Almayrac ... Emmanuelle Fabre
    A designed system to track homologous recombination (HR) in vivo demonstrates the importance of chromosome organization in the induction of global mobility in response to double-strand breaks and characterizes the role of two types of global motility in HR.

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