The use of tissue culture reduces the chemical modification of plant DNA, and this has lasting effects on gene expression in the plants and their descendants.

A combination of bioinformatics, protein biochemistry, and X-ray crystal structures reveals new bacterial proteins that are capable of binding to sterols.

Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.

Natural IgE supports epithelial cell growth and differentiation in healthy skin, but during chronic tissue inflammation, IgE drives tumour outgrowth of epithelial cells harbouring oncogenic mutations.

Parallel branches of the ERAD pathway regulate sterol synthesis at multiple steps via feedback inhibition.

The dynamical solutions exhibited by task-optimized recurrent neural networks, and their similarity to prefrontal cortex dynamics, depends strongly on the strength of neural noise and metabolic cost imposed during training.

Patients with different rs1990760 variants have a differential inflammatory response to severe SARS-CoV-2 infections, so that those with a TT genotype have an attenuated systemic inflammation and may not benefit from steroid therapy.

Diversification of a conserved cholesterol binder drives functional replacement of cholesterol with symbiont-produced sterols in corals living in nutrient-poor environments.

A novel quantitative framework to analyse the inner structure of tumour spheroids in terms of the mechanisms that underly growth.

The capture and export of a hydrophobic sterol molecule from the binding pocket of a Lam/GramD1 sterol-binding protein is unexpectedly mediated by water.