Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology

    Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

    Guanxing Chen, Qin Li ... Jiusheng Yan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex

    Kei Okatsu, Hayato Yamamoto ... Shuya Fukai
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
    Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
    1. Biochemistry and Chemical Biology

    Interrogating the structure and function of the human voltage-gated proton channel (hHv1) with a fluorescent noncanonical amino acid

    Emerson M Carmona, William N Zagotta, Sharona E Gordon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation

    Wilhelm Vaysse-Zinkhöfer, Enya Marie Catherine Alcindor ... David Paul Toczyski
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

    James Marks, Emma Young, Markus Hafner
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek Bansal, Maia Kinnebrew ... Diwakar Shukla
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Biochemistry and Chemical Biology

    Aggregation-dependent epitope sequence and modification fingerprints of anti-Aβ antibodies

    Ivan Talucci, Timon Leske ... Hans Michael Maric
    Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding selection and development of therapeutic antibodies in Alzheimer’s disease.
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson