Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110

   Wiktoria Sztangierska, Hubert Wyszkowski ... Agnieszka Kłosowska

   Recovery of proteins from aggregates by Hsp70 is boosted by the Hsp110 co-chaperone, which promotes abundant Hsp70 recruitment to aggregates and supports initial aggregate remodelling into small assemblies.
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)

   Fayang Zhou, Yuanyuan Zhang ... Qi Hu
3. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration

   Ana Patrícia Graça, Vadim Nikitushkin ... Gerald Lackner
4. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

   Jiale Zhou, Ding Zhao ... Zhanjun Li
5. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Genome-wide mapping of native co-localized G4s and R-loops in living cells

   Ting Liu, Xing Shen ... Zhihong Xue

   The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.
6. 1. Biochemistry and Chemical Biology

   A synthetic method to assay polycystin channel biophysics

   Megan Larmore, Orhi Esarte Palomero ... Paul G DeCaen
7. 1. Biochemistry and Chemical Biology
   2. Stem Cells and Regenerative Medicine

   Proteomic and functional comparison between human induced and embryonic stem cells

   Alejandro J Brenes, Eva Griesser ... Angus I Lamond
8. 1. Biochemistry and Chemical Biology

   DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids

   Emily L Dearlove, Chatrin Chatrin ... Danny T Huang

   Biochemical and structural analyses reveal direct ubiquitin modification of single-stranded nucleic acids, catalysed by the DTX3L ubiquitin ligase.
9. 1. Biochemistry and Chemical Biology

   Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

   Jonathan G Van Vranken, Jiaming Li ... Devin K Schweppe
10. 1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

    Ting-Wen Chen, Hsiao-Wei Liao ... Chung-Te Chang