Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology

    Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins

    Xukai Jiang, Yining Luo ... Jian Li
    Mapping the molecular interactions between polymyxins and hPepT2 enables rational design of safer lipopeptide antibiotics with reduced renal toxicity while retaining antibacterial activity.
    1. Biochemistry and Chemical Biology

    D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport

    Masataka Suzuki, Kenichiro Adachi ... Jumpei Sasabe
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Cell cycle-coupled CK1δ turnover, autoinhibition, and activity

    Fidel Emmanuel Serrano, Bianca Ruppert ... Michael Brunner
    In light of recent observations of how CK1δ is dynamically regulated, kinase activity and abundance are also regulated throughout the cell cycle primarily through phosphorylation at the C-terminal tail.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

    Bas de Boer, Thomas D Lamme ... Christopher T Schafer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    SARS-CoV-2 main protease inhibition through dimerization promotion by peptidomimetic inhibitors and disruption by ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Distinct effects of peptidomimetic inhibitors and ebselen on SARS-CoV-2 main protease dimerization reveal new strategies for antiviral drug design.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Sterol-Binding Cavity Underlies Sterol Recognition and Differential Activation of the ABCG5/G8

    Fatemeh Rezaei, Isra F Omar ... Jyh-Yeuan Lee
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics

    Jian Qiu, Martha A Bosch ... Martin J Kelly
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    NUDT2 loss defines quantitative limits for dinucleoside polyphosphate action on the cGAS–STING–TBK1 axis

    Paul Weiland, Renuka Dharani Shivakumar ... Gert Bange
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Glycolipid MPIase is essential for the TAT (Twin-Arginine Translocation) pathway

    Hanako Nishikawa, Nachi Yamamoto ... Ken-ichi Nishiyama
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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Highlights

    1. Biochemistry and Chemical Biology

    Lipid Transport: How membranes shape up for lipid transfer

    Takashi Hirashima, Toshiya Endo
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Biochemistry and Chemical Biology

    RNA: Searching for druggable targets

    Lana Heganovic, Luiz FM Passalacqua

Senior editors

  1. Volker Dötsch
    Goethe University, Germany
  2. Merritt Maduke
    Stanford University School of Medicine, United States
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors