Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

   A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland

   Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
2. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

   Conor J Howard, Nathan S Abell ... Nathan B Lubock

   Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.
3. 1. Biochemistry and Chemical Biology

   Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and density gradient ultracentrifugation: A Comparative Study

   Fang Kong, Megha Upadya ... Ming Dao
4. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Teichoic acids in the periplasm and cell envelope of Streptococcus pneumoniae

   Mai Nguyen, Elda Bauda ... Cecile Morlot
5. 1. Biochemistry and Chemical Biology

   Coordinated regulation of chemotaxis and resistance to copper by CsoR in Pseudomonas putida

   Meina He, Yongxin Tao ... Wenli Chen

   Pseudomonas putida coordinates chemotaxis and resistance to copper through the interaction between CheA and CsoR.
6. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

   Jiale Zhou, Ding Zhao ... Zhanjun Li

   The DRAM system enables antibody-free, bisulfite-free, and transcriptome-wide mapping of 5-methylcytosine in mRNA with high accuracy, stability, and sensitivity, even at ultralow RNA inputs.
7. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

   Pavla Nedbalová, Nikola Kaislerova ... Tomáš Doležal

   Adenosine produced by transmethylation may act as a sensor of the balance between cell activity and nutrient supply.
8. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   A General Mechanism for Initiating the General Stress Response in Bacteria

   Rishika Baral, Kristin Ho ... Niels Bradshaw
9. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

   Josep Fita-Torró, José Luis Garrido-Huarte ... Markus Proft
10. 1. Biochemistry and Chemical Biology

    Enzymatic protein fusions with 100% product yield

    Adrian CD Fuchs

    This enzymatic method enables highly specific and complete 1:1 protein conjugations with small molecules, solid supports, and other proteins, offering broad applicability across diverse biochemical and biotechnological applications.