Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Modular DNA Barcoding of Nanobodies Enables Multiplexed in situ Protein Imaging and High-throughput Biomolecule Detection

    Shilin Zhong, Ruiyu Wang ... Minmin Luo
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology

    Exploiting functional regions in the viral RNA genome as druggable entities

    Dehua Luo, Yingge Zheng ... Dengguo Wei
    SHAPE-MaP reveals functional RNA structures in the porcine epidemic diarrhea virus genome, enabling targeted siRNA design and offering a promising strategy to inhibit viral replication.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

    Mykola Roiuk, Marilena Neff, Aurelio A Teleman
    Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.
    1. Biochemistry and Chemical Biology

    RNA: Searching for druggable targets

    Lana Heganovic, Luiz FM Passalacqua
    A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology

    Engineering NIR-Sighted Bacteria

    Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

    Laura Sophie Kremer, Guanbin Gao ... Nils-Göran Larsson
    Regulation of mitochondrial DNA copy number is highly tissue-specific and context-dependent, particularly in the presence of disease.
    1. Biochemistry and Chemical Biology

    Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

    Prateeka Borar, Tapan Biswas ... Smarajit Polley
    Autocatalytic dual specificity of kinase IKK2/β, a Serine/Threonine kinase, is important for its substrate phosphorylation activity through an uncommon phosphorelay mechanism.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

    Yusuke Sakai, Saumik Sen ... Akihisa Terakita
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

    Jia He, Bo Chen ... Zhao Shan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
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Highlights

    1. Biochemistry and Chemical Biology

    Searching for druggable targets

    Lana Heganovic, Luiz FM Passalacqua
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
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