Browse our latest Cell Biology articles

Page 105 of 318
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    SSNA1 stabilizes dynamic microtubules and detects microtubule damage

    Elizabeth J Lawrence, Goker Arpag ... Marija Zanic
    SSNA1 is a potent microtubule stabilizer and novel sensor of microtubule damage, acting on both microtubule ends and lattices to regulate microtubule dynamics and protect microtubules against severing activity.
    1. Cell Biology

    A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress

    Nilay Nandi, Zuhair Zaidi ... Helmut Krämer
    The metal-dependent protein phosphatase Nilkantha, a Drosophila PPM1A/B homolog, dephosphorylates Acinus thereby restraining starvation-independent autophagy.
    1. Cell Biology
    2. Immunology and Inflammation

    RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice

    Bochuan Li, Ting Zhang ... Degang Liang
    METTL3 and m6A modifications could alleviate endothelial activation and atherogenesis through accelerated degradation of oscillatory flow-induced EGFR mRNA expression.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

    Lindsay B Case, Milagros De Pasquale ... Michael K Rosen
    Biochemical and cell biological data suggest a model of nascent integrin adhesion complex formation based on synergistic phase separation of pathways surrounding the focal adhesion kinase (FAK) and the adaptor protein p130Cas.
    1. Cell Biology
    2. Plant Biology

    Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors

    Julien Gronnier, Christina M Franck ... Cyril Zipfel
    The perception of endogenous RALF signaling peptides modulates the plasma membrane nanoscale organization of receptor kinases to regulate plant immune signaling.
    1. Cell Biology

    Female fertility and the zona pellucida

    Paul M Wassarman, Eveline S Litscher
    The ZP is a viscoelastic ECM that provides stability for contacts between projections from the innermost cumulus cells and oocyte microvilli that pass through the ZP and form gap junctions shown to be essential for oocyte growth and follicle development.
    1. Cell Biology
    2. Developmental Biology

    Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for intraflagellar transport of radial spokes

    Karl F Lechtreck, Yi Liu ... Pinfen Yang
    The cargo adapter ARMC2 mediates the association of radial spoke complexes to IFT trains ensuring radial spoke import and assembly in Chlamydomonas flagella.
    1. Cell Biology
    2. Immunology and Inflammation

    SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

    Manuela Ecker, Richard Schregle ... Jeremie Rossy
    Sorting nexin 9, a membrane curvature inducing protein, creates a distinct environment within clusters of the co-receptor CD28 and thereby allows T cell activation to proceed to a successful outcome.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

    Jeffrey Y Lee, Peter AC Wing ... Ilan Davis
    Single-molecule analysis of SARS-CoV-2 RNA identifies significant heterogeneity in cellular viral RNA levels and highlights slower replication kinetics for the Alpha variant compared to the Victoria strain.
    1. Cancer Biology
    2. Cell Biology

    Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

    Maxim I Maron, Alyssa D Casill ... David Shechter
    Biochemical, transcriptomic, and proteomic analyses reveal that protein arginine methyltransferases post-transcriptionally regulate intron detention—introns that persist in nuclear polyadenylated RNA—through methylation of RNA splicing and processing factors.