Browse our latest Cell Biology articles

Page 112 of 333
    1. Cell Biology

    High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast

    Masak Takaine, Hiromi Imamura, Satoshi Yoshida
    The first demonstration that cellular ATP homeostasis suppresses high volatility of cellular ATP levels to ensure proteostasis that prevents accumulation of cytotoxic protein aggregation.
    1. Cell Biology
    2. Developmental Biology

    Global analysis of cell behavior and protein dynamics reveals region-specific roles for Shroom3 and N-cadherin during neural tube closure

    Austin T Baldwin, Juliana H Kim ... John B Wallingford
    Tissue-level cell tracking and analysis of actomyosin and N-cadherin adhesion dynamics, coupled with disruption of the regulatory gene Shroom3, reveals region-specific cell behaviors along the anteroposterior axis during neural tube closure.
    1. Cell Biology
    2. Developmental Biology

    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

    Leyao Shen, Yilin Yu ... Courtney M Karner
    Proline is essential for osteoblast differentiation and bone formation by facilitating the production of proline-enriched osteoblast proteins.
    1. Cell Biology
    2. Developmental Biology

    Innervation modulates the functional connectivity between pancreatic endocrine cells

    Yu Hsuan Carol Yang, Linford JB Briant ... Didier YR Stainier
    Intercellular communication is critical for organ function, and the role of innervation in mediating this communication is of relevance to many fields, including developmental biology, neuroendocrinology, and disease pathophysiology.
    1. Cell Biology

    Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

    Michèle MG Hillege, Andi Shi ... Richard T Jaspers
    Muscle hypertrophy and regeneration are critically regulated by combination of TGF-β type I receptors in myofibres.
    1. Cell Biology

    The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast

    Houqing Yu, Roarke A Kamber, Vladimir Denic
    A novel mechanism by which a compartment-specific AAA+ complex mediating organelle biogenesis and protein quality control staves off induction of selective autophagy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Glypican-1 drives unconventional secretion of fibroblast growth factor 2

    Carola Sparn, Eleni Dimou ... Walter Nickel
    Identification of a heparan sulfate proteoglycan with a dedicated function in unconventional protein secretion reveals an intimate relationship between fibroblast growth factor 2 and Glypican-1 in cancer biology.
    1. Cell Biology
    2. Developmental Biology

    Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma

    Tsuyoshi Morita, Ken'ichiro Hayashi
    Actin-related protein 5 antagonizes the interaction of Pbx/Meis with myogenic regulatory factors such as MyoD and MyoG, which is involved in the recruitment of the BRG1-based switch/sucrose nonfermentable chromatin remodeling complex required for myogenic gene activation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

    Alex A Koch, James S Bagnall ... Andrew SI Loudon
    Dynamic interactions of core clock molecules are quantitively measured and mathematically modelled to reveal the hidden role of PER:CRY complexes in enhancing the mobility of CLOCK:BMAL1 to move to new DNA sites.
    1. Cell Biology

    Evolutionary conservation of centriole rotational asymmetry in the human centrosome

    Noémie Gaudin, Paula Martin Gil ... Juliette Azimzadeh
    Centriole rotational asymmetry, a structural property necessary for cytoskeletal organization in unicellular eukaryotes, is broadly conserved in the centrioles of human cells.