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Based on 3D visualization of fluorescently labeled cytoskeletal networks, an imaging platform is provided, which allows 3D network reconstruction, immersive visualization and quantification of local network properties serving as blueprints for functional modeling.

Mapping intermediate filaments in three dimensions reveals that the organization of these filaments differs across cell types.

A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.

Hyperphosphatemia, by itself and in the context of chronic kidney disease, contributes to iron restrictive anemia by directly targeting the liver and elevating proinflammatory cytokines and hepcidin, which contributes to widespread tissue injury, such as skeletal muscle wasting.

Activation of adiponectin receptors in young and aged mice induces changes in muscular metabolism via stimulation of AMPK and PGC-1a and ameliorates age-related muscle loss of function.

Rapid depletion of dynein from oocytes yielded new insights into acentrosomal pole organization and also led to the first evidence that the kinesin-5 motor BMK-1 plays a role in microtubule organization during C. elegans meiosis.

Quantitative proof that persistent cell migration in the timescale of hours relies on a feedback between polarized trafficking and protrusive activity stabilizing cell front.

Adult mouse fibroblasts maintain an embryonic gene expression signature, inherited from their organ of origin, that is important for organ homeostasis and fibrosis, and may assist in targeting fibrotic diseases in an organ-specific manner.

Macrophages use integrin-dependent 3D movement and cell protrusiveness, which control cell motility and space exploration as a prerequisite for optimal clearance of particles and dead cells by macrophage networks.

The general transcription factor TFIIH complex promotes the establishment and maintenance of chromosome structure during mitosis by altering the chromatin environment to allow for proper loading and function of the condensin complexes on chromatin.