Rab5 and Rab11 regulate hematopoietic homeostasis in Drosophila, and this process involves the JNK, Toll, and Ras/EGFR signaling pathways and autophagy.
Rebecca C Adikes, Abraham Q Kohrman ... David Q Matus
During organismal development, CDK activity at mitotic exit is predictive of future cell behavior, indicating whether a cell will divide again or enter a quiescent state.
Jaakko I Lehtimäki, Eeva Kaisa Rajakylä ... Pekka Lappalainen
Live-cell microscopy studies revealed that stress fibers can be generated de novo from the actin cortex without the involvement of stress fiber precursors.
An integrative study of five biological clocks in somatic and mental health indicate that one's biological age is best reflected by combining aging measures from multiple cellular levels.
Fernando R Balestra, Andrés Domínguez-Calvo ... Pierre Gönczy
TRIM37 prevents the formation of centriolar protein assemblies through an atypical de novo assembly pathway that would otherwise threaten genome integrity.
Alexander J Sercel, Alexander N Patananan ... Michael A Teitell
Applied pressure enables efficient isolated mitochondrial transfer and stable mitochondrial DNA (mtDNA) transplantation into a range of mtDNA-depleted cell types to restore respiration.
Sea3, a presumed subunit of the GATOR2 complex in fission yeast, is required for the GATOR1 function that attenuates TORC1 in parallel with the TSC complex and Gcn2 kinase.
Sara N Stahley, Lena P Basta ... Danelle Devenport
Planar cell polarity protein Celsr1 clusters into punctate assemblies through lateral cis-interactions to function as an organizer of intercellular Frizzled6 and Vangl2 asymmetry.
