Under fluid shear, living cells deform elliptically, align in flow direction, and rotate, from which their frequency-dependent viscoelastic properties can be inferred.
Mammalian cells were engineered to synthesize valine, a metabolic capacity that had been lost from the lineage of higher eukaryotes for >500 million years.
A population of p63+ Krt5- epithelial cells contribute to alveolar regeneration independent of the presence of ectopic tuft cells following viral infection.
Lactate-Ndrg1a signaling protects the kidney from hypoxic injury and functions partly by inducing reversible degradation of the ATP-demanding sodium-potassium ATPase pump.
Allison M Gicking, Tzu-Chen Ma ... William O Hancock
The motility of three different kinesin-dynein pairs were analyzed and found to be strikingly similar, suggesting that bidirectional transport is not regulated by motor type, but rather by scaffold, adapter, and regulatory proteins.
Drosophila enteroblasts form septate junctions, an apical domain and an internal lumen inside the midgut epithelium before they reach the gut surface, thereby maintaining the intestinal barrier as they integrate.
Lithocholic acid associates with skeletal muscle mass and plays an important role in skeletal muscle hypertrophy through activation of the bile acid receptor.
A new mechanism of Rvb1/Rvb2 proteins was found that couples transcription, mRNA granular localization and translation of select genes during glucose starvation stress.
Tolulope Sokoya, Jan Parolek ... Joost CM Holthuis
Organellar lipidomics and lipid reporter studies in intact cells reveal how disease-relevant mutations in a sphingolipid biosynthetic enzyme cause a wide-ranging perturbation of lipid distributions and membrane properties along the secretory pathway.
