Browse our latest Cell Biology articles

Neuronal glycolysis to restore energy consumed by ion movements is activated by engagement of the Na⁺/K⁺ pump, either directly by Na⁺ influx or indirectly, when Ca²⁺ influx is converted to Na⁺ accumulation by Na⁺/Ca²⁺ exchange.

The role of Isthmin-1 in muscle function is defined by using phosphoproteomics to identify distinct and overlapping signaling pathways between Isthmin-1 and insulin.

The structure of the yeast HOPS tethering complex suggests how this large complex may catalyze fusion by tethering Rab-decorated membranes and promoting the assembly of SNAREs.

A genetic manipulation of the Nrxn1/3^SS4+-Cbln1/2 complex reveals this signaling pathway has no role in synapse formation but functions to shape the NMDAR- and AMPAR-content at multiple types of synapses with distinct facets in diverse circuits.

Microfluidics and dynamic imaging allow systematic characterization of polarization kinetics in B lymphocytes and highlight the role of microtubules as master regulators of actin polymerization at the immune synapse.

A sophisticated classical mutagenesis assay with next-generation sequencing technology presents a benefit to future research on mutagenesis, DNA repair, and cancer.

A combination of genetic, electrophysiological, and modeling approaches reveals that presynaptic Rac1 is a key molecule that controls synaptic strength and plasticity by regulating the synaptic vesicle cycle steps controlling the number of fusion competent synaptic vesicles.

Publicly available gene expression data and proven methodologies for building model Gene Regulatory Networks are applied to successfully construct the IGF1 signaling GRN behind alveologenesis, serving as a pioneer in transforming how lung development and its associated diseases is approached.

Inactivation of SURF4 leads to impaired secretion of PCSK9 and apolipoproteins resulting in low plasma cholesterol without detrimental consequences to the liver.

The interaction between rDNA instability and proteostasis stress, two major aging hallmarks, underlies single-cell aging trajectories in yeast.