Browse our latest Computational and Systems Biology articles

The mechanism triggering HBV membrane fusion involves ERp57, a cellular protein disulfide isomerase, and ultimately leads to the exposition of a fusion peptide that was identified in the pre-S1 determinant.

A deep learning network can classify cardiac myocytes into drug-free and drugged categories and predict the impact of electrophysiological perturbation across the continuum of aging.

A mathematical model predicts that cell cycle duration acts as a transcriptional filter and directly affects cell diversity in early eukaryotic development.

Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.

Horizontal gene transfer between distantly related bacterial species is frequent and widespread and can be efficiently identified using alignment-free methods.

Ligand capture by cell surface receptor complexes sets the shape of the Nodal signaling pattern in zebrafish.

The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.

DNA concentration, cyclin levels, phosphatase activity, and CDK phosphorylation combine to directly link cell size to cell division.

Structural rearrangements of meiotic spindles during the transition from metaphase to anaphase can be controlled by local changes of microtubule dynamics, such as nucleation and/or turnover, and that katanin promotes microtubule turnover by severing microtubules near the chromosomes.

The ability of the T cell receptor to discriminate ligands is imperfect, allowing T cells to respond to ultra-low-affinity ligands.