Developmental Biology

Latest articles

1. 1. Cancer Biology
   2. Developmental Biology

   SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells

   Erik Oliemuller et al.

   SOX11+ breast tumours display reactivated embryonic developmental signalling and organogenetic features and are at elevated risk of developing metastases, so may benefit from more aggressive therapies.
2. 1. Developmental Biology

   A multi-layered and dynamic apical extracellular matrix shapes the vulva lumen in Caenorhabditis elegans

   Jennifer D Cohen et al.
3. 1. Developmental Biology
   2. Genetics and Genomics

   MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

   Meltem Weger et al.

   The glucose-sensing transcription factor MondoA regulates zebrafish epiboly via cholesterol biosynthesis genes including the human disease gene Nsdhl, revealing an unknown role for metabolic glucose signalling in vertebrate development.
4. 1. Developmental Biology
   2. Evolutionary Biology

   Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensis

   Cheng-Yi Chen et al.

   The dependence of Nematostella germ cell specification on zygotic Hedgehog pathway activity supports the hypothesis that the eumetazoan common ancestor segregated its germline by inductive signals rather than maternal determinants.
5. 1. Cell Biology
   2. Developmental Biology

   Alstrom syndrome gene is a stem cell-specific regulator of centriole duplication in the Drosophila testis

   Cuie Chen, Yukiko M Yamashita
6. 1. Developmental Biology

   Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration

   Shashank Gandhi et al.
7. 1. Cell Biology
   2. Developmental Biology

   Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2

   Yosuke Tona, Doris K Wu
8. 1. Cell Biology
   2. Developmental Biology

   Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts

   Amrutha Kizhedathu et al.

   Wnts can act synergistically to affect G2 arrest via transcriptional upregulation of a Checkpoint Kinase in the absence of any detectable DNA damage.
9. 1. Developmental Biology

   Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state

   Christian SM Helker et al.
10. 1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz et al.

    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.