Developmental Biology

Latest articles

1. 1. Developmental Biology

   Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

   Florian Schueder, Pierre Mangeol ... Frank Schnorrer

   The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
2. 1. Developmental Biology

   A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

   Vincent Loreau, Renate Rees ... Dirk Görlich

   A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.
3. 1. Developmental Biology
   2. Evolutionary Biology

   Metamorphosis of memory circuits in Drosophila reveals a strategy for evolving a larval brain

   James W Truman, Jacquelyn Price ... Tzumin Lee
4. 1. Developmental Biology

   Sex-specific role of myostatin signaling in neonatal muscle growth, denervation atrophy, and neuromuscular contractures

   Marianne E Emmert, Parul Aggarwal ... Roger Cornwall

   Myostatin signaling governs neonatal longitudinal muscle growth and neuromuscular contractures in a sex-dependent manner, identifying a potential avenue for contracture treatment and underscoring the need to consider sex as a biological variable in the pathophysiology of acquired neuromuscular disorders.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality

   Ankit Sabharwal, Mark D Wishman ... Stephen C Ekker

   A revertible Leigh Syndrome French Canadian Type (LSFC) disease model recapitulates the clinical phenotypes which can be rescued using a liver-specific genetic model therapy.
6. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

   Nan Wang, Jing He ... Kehkooi Kee

   The lncRNA landscapes in human germ cells are comprehensively profiled and the functional role of an lncRNA LNC1845 in regulating gene expression of a neighboring coding gene LHX8 is elucidated.
7. 1. Developmental Biology
   2. Neuroscience

   Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes

   Tuo Shi, Marielle O Beaulieu ... David W Raible

   Single-cell transcriptomic analysis defines hair cell and supporting cell types in the zebrafish inner ear, and reveals homologies with cells in the mammalian ear.
8. 1. Cell Biology
   2. Developmental Biology

   Control of craniofacial development by the collagen receptor, discoidin domain receptor 2

   Fatma F Mohamed, Chunxi Ge ... Renny T Franceschi
9. 1. Cell Biology
   2. Developmental Biology

   Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development

   Cayla E Jewett, Bailey L McCurdy ... Chad G Pearson

   Trisomy 21, the genetic cause of Down syndrome, produces elevated centrosome protein levels reducing intracellular trafficking to and from the centrosome thereby delaying primary ciliogenesis, ciliary signaling, and mouse cerebellar development.
10. 1. Cell Biology
    2. Developmental Biology

    Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function

    Huanqing Gao, Yiming Zhong ... Guozhi Xiao

    Biochemical and genetic approaches reveal how the focal adhesion protein kindlin-2 controls the liver development and homeostasis by reducing inflammation.