Browse our latest Genes and Chromosomes articles

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    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Decoding the centromeric nucleosome through CENP-N

    Satyakrishna Pentakota et al.
    A comprehensive structural, biochemical, and cell biological analysis reveals the molecular mechanism and significance of the conserved interaction of centromeric protein N (CENP-N) with the centromeric nucleosome.
    1. Cancer Biology
    2. Genes and Chromosomes

    Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells

    John P Vanden Heuvel et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
    1. Genes and Chromosomes

    Conserved noncoding transcription and core promoter regulatory code in early Drosophila development

    Philippe J Batut, Thomas R Gingeras
    Gene expression timing during Drosophila development is specified by multiple classes of RNA polymerase II core promoters, and the embryonic transcriptome includes thousands of evolutionarily conserved long noncoding RNAs.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Cis-regulatory evolution integrated the Bric-à-brac transcription factors into a novel fruit fly gene regulatory network

    Maxwell J Roeske et al.
    The conserved biochemical activity of the duplicate Bab transcription factors were integrated into the regulatory hierarchy of an evolving gene regulatory network by binding site gains in a target gene's cis-regulatory region.
    1. Cell Biology
    2. Genes and Chromosomes

    Context-dependent deposition and regulation of mRNAs in P-bodies

    Congwei Wang et al.
    An unbiased screen using various stresses reveals selective mRNA transport into P-bodies, in which mRNAs are either stored or decayed in a process that may promote chronological lifespan in yeast.
    1. Genes and Chromosomes

    Telomere repeats induce domains of H3K27 methylation in Neurospora

    Kirsty Jamieson et al.
    Vast regions of facultative heterochromatin marked by methylation of lysine 27 on histone H3 depend on their proximity to chromosome ends and can be induced ectopically by insertion of telomere repeats.
    1. Cell Biology
    2. Genes and Chromosomes

    cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool

    Vladimir Camarena et al.
    cAMP is identified to play a novel role in regulating DNA demethylation and gene transcription by augmenting the intracellular reactive Fe(II) pool.
    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Natural variation in stochastic photoreceptor specification and color preference in Drosophila

    Caitlin Anderson et al.
    Binding site affinity and transcription factor levels are finely tuned in nature to regulate stochastic expression, setting the ratio of alternative photoreceptor fates and determining color preference.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

    Xinan H Yang et al.
    Transcription-factor-dependent noncoding RNA transcription illuminates components of a transcription-factor-dependent gene regulatory network that includes enhancer-associated long noncoding RNAs and is necessary for cardiac rhythm.