Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics
    2. Neuroscience

    Behavioral Inheritance: When mothers leave their mark

    Raquel Barajas-Azpeleta, Kausik Si
    Progeny can inherit parental experiences through altered brain chemistry.
    Version of Record
    Insight
    1. Developmental Biology
    2. Genetics and Genomics

    Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism

    Samuel Andrew Malone, Georgios E Papadakis ... Paolo Giacobini
    Mouse in vivo and in vitro analysis and human genetic screening highlight the role of anti-Müllerian hormone (AMH) signaling in GnRH neuronal development and function, and identify mutations in AMH and AMHR2 in CHH patients.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

    Min Jung, Daniel Wells ... Donald F Conrad
    A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
    1. Evolutionary Biology
    2. Genetics and Genomics
    Medaka illustration

    The Natural History of Model Organisms: The untapped potential of medaka and its wild relatives

    Leon Hilgers, Julia Schwarzer
    Studies of medaka and other ricefishes in the wild could provide insights in fields such as evolutionary biology, development and cancer research.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Improved CUT&RUN chromatin profiling tools

    Michael P Meers, Terri D Bryson ... Steven Henikoff
    Enhancements to the CUT&RUN antibody-targeted nuclease strategy for chromatin profiling include an improved affinity-cleavage fusion protein and digestion protocol, and a simplified calibration strategy.
    1. Genetics and Genomics

    The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

    Karole N D'Orazio, Colin Chih-Chien Wu ... Rachel Green
    Cue2 is an endonuclease that cleaves mRNA in the A site of the lagging ribosome upon ribosome collision events.
    1. Genetics and Genomics
    2. Neuroscience

    The ion channel ppk301 controls freshwater egg-laying in the mosquito Aedes aegypti

    Benjamin J Matthews, Meg A Younger, Leslie B Vosshall
    The ion channel ppk301 is required for the evaluation of water purity during egg-laying, which promotes offspring survival in the arboviral vector mosquito Aedes aegypti.
    1. Genetics and Genomics
    2. Neuroscience

    Mosquitos: The taste of water

    W Daniel Tracey
    Female mosquitos require a specific ion-channel protein to sense the presence of fresh water in which they can lay their eggs.
    Version of Record
    Insight
    1. Evolutionary Biology
    2. Genetics and Genomics

    Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA

    Sasha A Langley, Karen H Miga ... Charles H Langley
    Genomic polymorphism across centromeric regions of humans is organized into large-scale haplotypes with great diversity, including entire Neanderthal centromeres.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome plasticity in Candida albicans is driven by long repeat sequences

    Robert T Todd, Tyler D Wikoff ... Anna Selmecki
    Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.