Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A bacterial membrane sculpting protein with BAR domain-like activity

    Daniel A Phillips, Lori A Zacharoff ... Sarah M Glaven
    Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    RNase III-mediated processing of a trans-acting bacterial sRNA and its cis-encoded antagonist

    Sarah Lauren Svensson, Cynthia Mira Sharma
    Functional characterization of a pair of cis-encoded antisense RNAs reveals a role for RNase III and antisense regulation in the biogenesis and regulatory activity of a bacterial virulence factor-regulating small RNA.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing

    Yiquan Wang, Ruipeng Lei ... Nicholas C Wu
    The local fitness landscape of an antigenic region in influenza neuraminidase was determined by combinatorial mutagenesis and next-generation sequencing.
    1. Microbiology and Infectious Disease

    HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave

    Farina Karim, Inbal Gazy ... Alex Sigal
    HIV infection increases SARS-CoV-2 disease severity and alters immune cell dynamics in a beta variant dominated infection wave.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

    Yong Fu, Kevin M Brown ... L David Sibley
    Live-cell imaging and biochemical studies reveal that bradyzoites exhibit reduced Ca2+ stores, dampened calcium responses, and reduced energy levels consistent with their quiescent sate, but that they rapidly respond to environmental conditions to emerge from dormancy.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A genome-phenome association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

    Weiwei Yang, Yu-Cheng Lin ... Laurence Ettwiller
    A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Public Health: Add mass spectrometry to the pandemic toolbox

    Bart Van Puyvelde, Maarten Dhaenens
    A new protocol step improves robustness and ease-of-use for mass spectrometry in the clinic, opening the door to mass deployment to monitor infectious agents.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

    Virender Kumar Pal, Ragini Agrawal ... Amit Singh
    A gaseous signaling molecule hydrogen sulfide stimulates mitochondrial bioenergetics, maintains glutathione redox poise, and suppresses ROS to subvert viral rebound in latently infected CD4+ T cells from HIV subjects.
    1. Microbiology and Infectious Disease

    Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

    Fred D Mast, Peter C Fridy ... Michael P Rout
    A large repertoire of nanobodies that target discrete regions of SARS-CoV-2 spike shows effective neutralization against variants of concern with many pairwise combinations resistant to escape and demonstrating synergistic neutralization activities.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

    Erik Bakkeren, Joana Anuschka Herter ... Wolf-Dietrich Hardt
    Bacterial gut pathogens that invade into host tissues during infection can boost the spread and accumulation of plasmids over time by forming reservoirs containing these plasmids within host tissues.