Browse our latest Microbiology and Infectious Disease articles

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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial – BCPP/Ya Tsie trial

    Lerato E Magosi, Yinfeng Zhang ... Marc Lipsitch
    HIV transmissions into intervention communities from control communities in the Botswana/Ya Tsie trial were similar to the reverse at baseline, and 10 times more common post-baseline, concordant with a predicted benefit of a universal test-and-treat HIV prevention intervention.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection

    Danielle Beckman, Adele MH Seelke ... Eliza Bliss-Moreau
    Fetal Zika virus’ direct infection of the brain causes neuroanatomical pathology that tracks with the brain development, following a caudal-to-rostral trajectory, even in individuals who do not develop microcephaly.
    1. Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment

    Xi Zhang, Xiaolin Zhang ... Yaling Han
    After myocardial infarction, gut microbiota affects platelet aggregation rate by regulating the absorption and metabolism of ticagrelor.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

    Francesca D'Angelo, Elena Fernández-Fueyo ... Gregory Bokinsky
    The intracellular network that distributes iron-sulfur clusters in bacteria is surprisingly 'plug and play' with iron-sulfur enzymes acquired from distantly related species, whereas the intracellular electron transfer network often needs plug adapters to connect with foreign enzymes.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection

    Meghan E Garrett, Jared G Galloway ... Julie M Overbaugh
    Sera from vaccinated subjects bound additional linear epitopes compared to sera from individuals with mild infection, in addition the pathways of escape from antibodies from vaccination were more uniform than those from mildly infected individuals.
    1. Microbiology and Infectious Disease

    Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector

    Lei Song, Jingjing Luo ... Zhao-Qing Luo
    A novel bacterial protease activated by a eukaryote-specific factor attacks a host protein involved in cytoskeleton organization to inhibit cell migration during Legionella pneumophila infection.
    1. Microbiology and Infectious Disease

    Ribonucleotide reductase, a novel drug target for gonorrhea

    Jana Narasimhan, Suzanne Letinski ... Arthur Branstrom
    Novel small molecule inhibitors act against Neisseria including multi-drug resistant isolates by uniquely targeting RNR thereby enabling single pathogen therapy whilst sparing the microbiome.
    1. Microbiology and Infectious Disease

    Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding

    R Christopher D Furniss, Nikol Kaderabkova ... Despoina AI Mavridou
    Disruption of disulfide bond formation sensitizes resistant Gram-negative bacteria expressing β-lactamases and mobile colistin resistance enzymes to currently available antibiotics.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    m6A modifications regulate intestinal immunity and rotavirus infection

    Anmin Wang, Wanyiin Tao ... Shu Zhu
    RNA m6A level is dually regulated during RV infection and development, METTL3 deficiency in IECs results in increased resistance to rotaviral infection through reduced m6A modificaitons on Irf7.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution of host-microbe cell adherence by receptor domain shuffling

    EmilyClare P Baker, Ryan Sayegh ... Matthew F Barber
    Rapid evolution and gene conversion of a primate cell surface receptor family blocks recognition by pathogenic bacteria.