Browse our latest Microbiology and Infectious Disease articles

Page 89 of 169
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Mixed cytomegalovirus genotypes in HIV-positive mothers show compartmentalization and distinct patterns of transmission to infants

    Juanita Pang, Jennifer A Slyker ... Judith Breuer
    Genomic analyses provide new insights into natural history and pathogenesis of cytomegalovirus infection and suggest new testable hypotheses that could be important for the design and implementation of new vaccines.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

    E Fabian Cardozo-Ojeda, Elizabeth R Duke ... Joshua T Schiffer
    Mathematical models reveal the conditions required for long-term HIV remission using autologous transplantation of hematopoietic stem cells.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis

    Laura Whitworth, Jacob Coxon ... Lalita Ramakrishnan
    In this ideal example of pharmacogenomics, individuals with a common variant in a gene encoding for an inflammatory lipid mediator benefit selectively from standard-of-care anti-inflammatory treatment used for tuberculous meningitis.
    1. Microbiology and Infectious Disease

    Bacterial symbiont subpopulations have different roles in a deep-sea symbiosis

    Tjorven Hinzke, Manuel Kleiner ... Stephanie Markert
    Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A unique chromatin profile defines adaptive genomic regions in a fungal plant pathogen

    David E Cook, H Martin Kramer ... Bart P H J Thomma
    Assessment of DNA methylation, histone modifications, and DNA accessibility revealed that physical DNA characteristics are associated with adaptive genome evolution in the broad host range plant pathogenic fungus Verticillium dahliae.
    1. Microbiology and Infectious Disease

    Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

    Michaela Gregorova, Daniel Morse ... Ruth C Massey
    Post-acute or long-COVID is associated with bystander T-cell activation and a recurring antimicrobial resistant, bacterial ventilator-associated pneumonia.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

    Sean R Cuddy, Austin R Schinlever ... Anna R Cliffe
    Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
    1. Microbiology and Infectious Disease

    Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

    Shehryar Ahmad, Kara K Tsang ... John C Whitney
    A widespread family of chaperones functions to stabilize membrane protein effectors by mimicking transmembrane helical environments and promotes effector export by the bacterial type VI secretion system.
    1. Microbiology and Infectious Disease

    HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

    Hataf Khan, Rebecca P Sumner ... Greg J Towers
    HIV-1 Vpr antagonises innate immune sensing of viral and non-viral stimuli by preventing activated IRF3 and NF-κB nuclear transport.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

    Ilona Rissanen, Robert Stass ... Thomas A Bowden
    An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.