Marc A Schureck, Joseph E Darling ... Sanjay A Desai
A high-resolution structure reveals how the RhopH complex traffics within Plasmodium-infected human erythrocytes to serve divergent, essential functions.
Cristina Herencias, Jerónimo Rodríguez-Beltrán ... Álvaro San Millán
Acquisition of antibiotic resistance plasmids induces collateral sensitivity to clinically relevant antibiotics in Escherichia coli, paving the way for targeted 'anti-plasmid' therapies able to preferentially eliminate plasmid-carrying bacteria.
A single dose of a characterized motility-deficient mutant was sufficient to induce robust anti-protein antibodies' response and cross-protective immunity against death and colonization in two different animal models of leptospirosis.
Elizabeth A Landis, Angela M Oliverio ... Benjamin E Wolfe
In the most comprehensive survey of sourdough starter biodiversity, this work identifies processes that control the diversity and function of sourdough microbiomes at a continental scale.
Lara Urban, Andre Holzer ... Maximilian R Stammnitz
From now on, nanopore metagenomics can be used to monitor aquatic environments with high spatiotemporal resolution, by use of a benchmarked, standardised and cost-effective workflow.
David W Hawman, Kimberly Meade-White ... Heinz Feldmann
A mouse-adapted strain of Crimean-Congo hemorrhagic fever virus that recapitulates human disease in wild-type mice significantly improves our ability to study Crimean-Congo hemorrhagic fever virus pathogenesis.
Martin Steen Mortensen, Morten Arendt Rasmussen ... Søren Johannes Sørensen
Modeling weighted transfer ratios enable statistical analysis of maternal–infant transfer at a more general level and can indicate whether any transfer is persistent, transient, or originates from alternate sources.
Whereas SARS-CoV-2 utilizes cathepsins to enter most cell lines, human airway organoids revealed that entry into relevant cells is dependent on serine proteases, which can be targeted for treatment.
Jack Alfred Bryant, Faye C Morris ... Ian R Henderson
Analysis of the E. coli protein DolP reveals the first dual BON-domain structure and identifies phospholipid binding as a new mechanism for protein localisation to the outer membrane division site.