An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.
Dylan H Morris, Velislava N Petrova ... Colin A Russell
Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.
Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.
Applying bioorthogonal chemistry to the zebrafish/Mycobacterium marinum model of tuberculosis reveals that the virulence lipid PDIM must spread into epithelial cells in order for mycobacteria to establish infection.
Yiska Weisblum, Fabian Schmidt ... Paul D Bieniasz
SARS-CoV-2 spike variants that resist neutralization by therapeutic antibodies or convalescent plasma can be generated in the laboratory and exist at low frequency in natural populations.
Christine R Collins, Fiona Hackett ... Michael J Blackman
Genetic analysis identifies an enzyme of the malaria parasite that is required to seal its host red blood cell membrane upon invasion, a key requirement of this important intracellular pathogen.
Soner Yildiz, João P Pereira Bonifacio Lopes ... Mirco Schmolke
A respiratory tissue-associated commensal Lactobacillus strain confers colonization resistance to Streptococcus pneumoniae, when applied therapeutically in a post influenza virus super-infection model.
