Physics of Living Systems

Latest articles

1. 1. Physics of Living Systems
   2. Structural Biology and Molecular Biophysics

   Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

   Daniel Porto et al.

   Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
2. 1. Microbiology and Infectious Disease
   2. Physics of Living Systems

   Gut bacterial aggregates as living gels

   Brandon H Schlomann, Raghuveer Parthasarathy

   A theory of gut bacterial aggregation produces a cluster size distribution that matches that of several strains observed in zebrafish, suggesting principles generally applicable to the vertebrate gut.
3. 1. Evolutionary Biology
   2. Physics of Living Systems

   Evolution of irreversible somatic differentiation

   Yuanxiao Gao et al.

   Irreversible differentiation into somatic cells is evolutionarily optimal if changing cell phenotype is costly, a few somatic cells already improve the organism's performance, and the organism is large enough.
4. 1. Cell Biology
   2. Physics of Living Systems

   Quantitative theory for the diffusive dynamics of liquid condensates

   Lars Hubatsch et al.
5. 1. Microbiology and Infectious Disease
   2. Physics of Living Systems

   Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

   Mona Seifert et al.

   High-throughput and ultra-stable magnetic tweezers reveal that Remdesivir induces a long-lived backtrack pause upon incorporation by the coronavirus polymerase, and SARS-CoV-2 is able to evade interferon-induced antiviral ddhCTP.
6. 1. Microbiology and Infectious Disease
   2. Physics of Living Systems

   Single-cell growth inference of Corynebacterium glutamicum reveals asymptoticallylinear growth

   Joris Jan Boudewijn Messelink et al.
7. 1. Computational and Systems Biology
   2. Physics of Living Systems

   First-principles model of optimal translation factors stoichiometry

   Jean-Benoît Lalanne, Gene-Wei Li
8. 1. Microbiology and Infectious Disease
   2. Physics of Living Systems

   A morphological transformation in respiratory syncytial virus leads to enhanced complement deposition

   Jessica P Kuppan et al.

   Respiratory syncytial virus produces filamentous particles that change shape when the viral matrix detaches from the viral membrane, and this change in shape results in enhanced deposition of complement proteins, with potential downstream consequences.
9. 1. Cell Biology
   2. Physics of Living Systems

   Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics

   Mohammad Mofatteh et al.

   Latest advances in biological timing studies substantiate an emerging concept of autonomous clocks that are normally entrained by the cell cycle and/or the circadian clock to run in synchrony, but have evolved to run independently to regulate different cellular events.
10. 1. Physics of Living Systems

    Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers

    Tianfa Xie et al.

    Radial alignment in confined cell monolayers with isotropic actin network is found to be mediated by the condensation tendency and tissue-scale actin gradient.