Physics of Living Systems

Physics of Living Systems

eLife publishes research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Physics of Living Systems

    Alternation emerges as a multi-modal strategy for turbulent odor navigation

    Nicola Rigolli, Gautam Reddy ... Massimo Vergassola
    A tracking animal's decision to intermittently pause and sniff the air reflects its belief that it is far downwind of the odor source, where benefits of sensing rare airborne cues outweigh the cost of pausing.
    1. Physics of Living Systems

    Navigation: Where is that smell coming from?

    Samuel Brudner, Thierry Emonet
    Computational model reveals why pausing to sniff the air helps animals track a scent when they are far away from the source.
    Formats available:
    • HTML
    • PDF
    1. Evolutionary Biology
    2. Physics of Living Systems

    Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

    Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad
    Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Recovering mixtures of fast-diffusing states from short single-particle trajectories

    Alec Heckert, Liza Dahal ... Xavier Darzacq
    Tracking proteins in live cells is challenging due to technical limitations and biological complexity, but approaches based in Bayesian nonparametrics stand a decent chance at recovering a target protein's dynamic profile from noisy data.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

    Mark A Zaydman, Alexander S Little ... Arjun S Raman
    The emergent organization of bacterial proteomes—the integration of proteins into collective networks that encode function—can be defined purely from spectral analysis of ortholog covariation across extant diversity.
    1. Physics of Living Systems

    Control of nuclear size by osmotic forces in Schizosaccharomyces pombe

    Joël Lemière, Paula Real-Calderon ... Fred Chang
    The volume of the nucleus is dictated by a balance of colloid osmotic forces from the nucleoplasm and cytoplasm.
    1. Cell Biology
    2. Physics of Living Systems

    Self-organization of kinetochore-fibers in human mitotic spindles

    William Conway, Robert Kiewisz ... Daniel J Needleman
    A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.
    1. Physics of Living Systems

    3D single cell migration driven by temporal correlation between oscillating force dipoles

    Amélie Luise Godeau, Marco Leoni ... Daniel Riveline
    A phase shift between local contractions drives 3D cell motility in experiments and in model or how a finite area in the dipole-quadrupole space explains cell motion with zero total force.


    1. Physics of Living Systems

    Searching for smells

    Samuel Brudner, Thierry Emonet
    1. Physics of Living Systems

    Cancer: Cells under pressure

    Dhiraj Indana, Ovijit Chaudhuri

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors