Michael James Chambers, Sophia B Scobell, Meru J Sadhu
The innate immune protein PKR, which is inhibited by viral proteins that mimic its natural substrate, has access to a wide spectrum of inhibitor-evading mutations that maintain natural substrate binding.
In congenital stationary night blindness type 2, Cav3 channels may maintain cone synaptic output and visual function provided that the nonconducting role of Cav1.4 in cone synaptogenesis remains intact.
Rachel Sharninghausen, Jiwon Hwang ... Ryan D Baldridge
A generalizable approach to identify sequence features driving degradation from the endoplasmic reticulum (ER) provides useful tools for enabling ER-localized protein degradation.
Programmed cell death during plant development (dPCD) is crucial for Arabidopsis thaliana root defense, limiting microbial invasion and maintaining a balanced relationship with beneficial microbes.
All-atom molecular dynamics simulations revealed both direct and indirect salt effects and led to an amino-acid composition-based predictor for four classes of salt dependence of IDP phase separation.
Abolishing opposing hair cell orientation in mouse otolith and zebrafish neuromast organs preserves segregation of afferent innervation but affects zebrafish mechanotransduction and mouse vestibular reflexes.
Adding suppressors of spontaneous differentiation enables precise control of human induced pluripotent stem cell (hiPSC) status in suspension culture conditions and leads to scalable and automated cell therapy using hiPSCs.
The dynamic transcription responses of the human fungal pathogen Candida glabrata during macrophage infection is revealed and a novel transcription factor important for the responses to macrophage, proliferation within macrophage, as well as anti-fungal drug resistance has been discovered.
