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Bactericidal/permeability-increasing protein (BPI) from the scorpionfish Sebastes schlegelii escapes detection by BPI autoantibodies derived from people with cystic fibrosis and reveals excellent anti-inflammatory potency as well as profound antimicrobial activity towards Pseudomonas aeruginosa, including multiple drug-resistant strains.

A GWAS meta-analysis for OPLL identified fourteen significant genomic loci and a subsequent Mendelian randomization study provided genetic evidence for a causal effect of obesity on the pathogenesis of OPLL, especially one of its subtypes, thoracic OPLL.

Proteomic and metabolomic analyses reveal how mannose exerts its anticancer activity.

The medial prefrontal cortex and orbitofrontal cortex work in concert to match state representations from feedback to those at choice, and the strength of these common neural codes predict credit assignment precision.

In an autoimmune environment B cells mature from spontaneous germinal centers into transcriptomically and phenotypically diverse memory and antibody-secreting cells but maintaining shared clonal and potential self-reactive specificities which has important implications for pathogenic cell targeted depletion.

The disease-associated RNA binding protein Nab2 is required to inhibit m⁶A RNA methylation in female Drosophila neuronal tissue and controls key splicing events such as sex-specific splicing of the Sex-lethal RNA.

Investigating microbial communities in a spatial environment in silico suggests that spatial structure promotes higher coexistence by allowing spatial self-organization, but can hinder coexistence by weakening interactions mediated through diffusible metabolites.

Live imaging and physical perturbations of spindles with unfocused poles reveal that mammalian spindle length emerges locally from kinetochore-fibers, but that global cues from focused spindle poles are needed to coordinate k-fibers across space and time and accurately segregate chromosomes.

TBX5 lineage tracing and high resolution single cell transcriptomics uncover the predominance of first heart field development during human-induced pluripotent stem cell cardiac differentiation.