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The important oncogene KRasG13C can be targeted by covalently binding nucleotide-analogues, resulting in a locked protein that can no longer induce oncogenic signaling.

The ability to discriminate highly overlapping events in memory is a multistage process supported by a network of brain regions and neocortical–hippocampal interactions.

The integration of established psychological and biological models of pain suggests novel interventions to prevent pain persistence.

The dengue and yellow fever mosquito first specialized on humans about 5000 years ago, but appears to use the same genes to thrive in urban environments today.

A comprehensive resource based on analysis of the responses of embryonic ectoderm cells to signals from the 'organizer' (the node) including transcriptional responses and epigenetic changes with fine temporal dynamics, predicted regulatory interactions, and conservation among vertebrates.

Quantitative proteomic analysis shows that recessive Ryr1 mutations not only decrease the content of RyR1 protein in muscle, but also affect the content of many other proteins involved in a variety of biological processes.

An iterative procedure using language models allows the generation of sequences from protein families, which score similarly to natural and experimentally validated sequences, with particular promise for small families.

THINGS-data reflects three large-scale neuroimaging and behavioral datasets of object processing in humans, comprising densely sampled functional MRI and magnetoencephalographic recordings, as well as 4.70 million similarity judgments in response to thousands of photographic images for up to 1854 objects.

Force applied to the cell membrane reversibly changes a voltage-insensitive gating step of a prokaryotic voltage-gated sodium channel.

XTABLE is the first easy-to-use bioinformatic solution that has been conceived and designed solely to interrogate the transcriptomes of premalignant stages of lung squamous cell carcinoma (LUSC) and enhance the development of LUSC prevention and detection strategies.