The medial prefrontal cortex and orbitofrontal cortex work in concert to match state representations from feedback to those at choice, and the strength of these common neural codes predict credit assignment precision.
Carlos Castrillon, Lea Simoni ... Michael C Carroll
In an autoimmune environment B cells mature from spontaneous germinal centers into transcriptomically and phenotypically diverse memory and antibody-secreting cells but maintaining shared clonal and potential self-reactive specificities which has important implications for pathogenic cell targeted depletion.
The disease-associated RNA binding protein Nab2 is required to inhibit m6A RNA methylation in female Drosophila neuronal tissue and controls key splicing events such as sex-specific splicing of the Sex-lethal RNA.
Alexander Lobanov, Samantha Dyckman ... Babak Momeni
Investigating microbial communities in a spatial environment in silico suggests that spatial structure promotes higher coexistence by allowing spatial self-organization, but can hinder coexistence by weakening interactions mediated through diffusible metabolites.
Live imaging and physical perturbations of spindles with unfocused poles reveal that mammalian spindle length emerges locally from kinetochore-fibers, but that global cues from focused spindle poles are needed to coordinate k-fibers across space and time and accurately segregate chromosomes.
TBX5 lineage tracing and high resolution single cell transcriptomics uncover the predominance of first heart field development during human-induced pluripotent stem cell cardiac differentiation.
Sixteen new mermithid nematodes associated with their insect hosts are discovered from mid-Cretaceous Kachin amber and they are more abundant in non-holometabolous insect hosts, revealing what appears to be a vanished history of nematodes parasitism.
Eike K Mahlandt, Sebastián Palacios Martínez ... Joachim Goedhart
Optogenetic activation of Rho GTPases provides spatiotemporal control over endothelial cell shape and enables control over endothelial barrier function by manipulating the cell-cell overlap with blue light.
Development of an enrichment method to facilitate RNA-sequencing of the Lyme disease pathogen from inside of ticks during a bloodmeal provides new candidates for genes important for disease transmission.
