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EZH2/cMET may serve as biomarkers to stratify chondrosarcoma patients for cMET inhibitor treatment.

Dalpiciclib could partially abrogate ER nuclear transportation induced by pyrotinib in HER2+HR+ breast cancer and CALML5 could serve as a potential risk factor in the treatment of HER2+HR+ breast cancer.

Hextuple knockout of key active zone proteins strongly reduces the pool of synaptic vesicles available for release, but synapse formation persists.

Computational methods based on both sequence and structure show evidence that tyrosine kinases are energetically biased to populate the 'DFG-out' type-II inhibitor binding conformation relative to serine/threonine kinases.

Overexpression of hAC8 engages complex, coordinate adaptation 'circuity' that has evolved in mammalian cells to defend against stress that threatens health or life, and may be important for proper healing in disease states such as heart infarction or failure.

Bayesian inference identifies hidden dynamics underlying noisy cell division data.

Drosophila larvae foraging adapt to different food quality and distributions modulating specific motor programs, as revealed by behavioral and modeling experiments.

Insight into pre-existing SARS-CoV-2-specific T cell responses caused by heterologous T cell immunity directed against dissimilar epitopes, mediated by a public T cell receptor.

A synaptic circuit through which 'what' streams of information associated with the lateral entorhinal cortex may influence 'where' streams of information associated with the medial entorhinal cortex prior to their integration in the hippocampus.

Emotional learning retroactively promotes memory integration for previously neutral events into episodic memory to foster future event predictions, through rapidly stimulating trial-specific reactivation of overlapping memory traces and reorganization of associated memories among the amygdala, hippocampal, and neocortical circuits.