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    1. Chromosomes and Gene Expression

    Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters

    Yi-Jun Sheu, Risa Karakida Kawaguchi ... Bruce Stillman
    The localization of Rad53 cell cycle checkpoint kinase to many gene promoters and the dynamic changes in response to replication stress suggests that the kinase may coordinate genome stability and gene expression.
    1. Chromosomes and Gene Expression

    Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit

    Shoji Tane, Keishi Shintomi ... Tatsuya Hirano
    In vitro assays using Xenopus egg extracts provide evidence that mitosis-specific loading of condensin I is accelerated by phosphorylation of the N-terminal tail of its kleisin subunit.
    1. Cell Biology
    2. Immunology and Inflammation

    A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage

    Jérémy Argenty, Nelly Rouquié ... Renaud Lesourne
    Mouse deficiencies for the dynein-binding protein LIS1 reveal different cell division mechanisms across T-cell subsets.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes

    Yi Feng, Rafik Neme ... Laura F Landweber
    The comparison of three ciliate species that share complex pathways for natural genome editing allows capture of intermediate states in the acquisition of scrambled genes and elucidating a pathway for the origin and evolution of extremely rearranged chromosomes.
    1. Computational and Systems Biology
    2. Neuroscience

    Emergent color categorization in a neural network trained for object recognition

    Jelmer P de Vries, Arash Akbarinia ... Karl R Gegenfurtner
    Human-like color categories emerge in a Deep Neural Network trained only on object recognition.
    1. Neuroscience

    Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity

    Shruti Thapliyal, Kristin L Arendt ... Lu Chen
    Synaptic silencing-induced homeostatic enhancement of presynaptic glutamate release is mediated by the postsynaptic retinoic acid-dependent brain-derived neurotrophic factor (BDNF) synthesis from dendritically targeted BDNF transcripts, leading to retrograde activation of presynaptic tropomyosin receptor kinase B receptors.
    1. Physics of Living Systems
    2. Plant Biology

    Environmental morphing enables informed dispersal of the dandelion diaspore

    Madeleine Seale, Oleksandr Zhdanov ... Naomi Nakayama
    The dandelion diaspore changes its shape depending on the moisture levels in the air, and this morphing enhances the dispersal potential of the seeds regardless of the weather conditions.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Deep learning-driven insights into super protein complexes for outer membrane protein biogenesis in bacteria

    Mu Gao, Davi Nakajima An, Jeffrey Skolnick
    An example of a deep learning-based strategy to discover novel protein-protein interactions and predict their complex structures at high accuracy.
    1. Neuroscience

    Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum

    Sophia S Loschky, Giovanna Maria Spano ... Chiara Cirelli
    In the mouse cerebellum, the number of branched synapses is reduced in half after sleep compared to after wake.
    1. Neuroscience

    Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period

    Sarah E Canetta, Emma S Holt ... Christoph Kellendonk
    Prefrontal PV interneuron activity during development is necessary for prefrontal circuit maturation, supporting adult prefrontal network function and cognitive flexibility.