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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A billion years arms-race between viruses, virophages, and eukaryotes

    Jose Gabriel Nino Barreat, Aris Katzourakis
    Phylogenetic analyses of the four core virion proteins support a new evolutionary model for the origin of the main groups of eukaryotic viruses in the kingdom Bamfordvirae.
    1. Neuroscience

    Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice

    Leslie D Claar, Irene Rembado ... Christof Koch
    Activating deeper layers of the cortex using cortical electrical stimulation triggers the activation of thalamic nuclei through trans-synaptic signaling, which can result in a range of complex responses that can be detected using EEG signals.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

    Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard
    Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.
    1. Cell Biology

    An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo

    Peter H Lee, Michael Anaya ... Kai Zinn
    The cell-surface protein Stranded at second is a targeting ligand for extracellular vesicles that can deliver dArc1 capsids containing dArc1 mRNA to distant cells in vivo.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

    Wenxin Zhang, Taki Nishimura ... Sharon A Tooze
    cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope

    Swati Tyagi, Juliana S. Capitanio ... Martin W. Hetzer
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    TCR-pMHC complex formation triggers CD3 dynamics

    Floris J. van Eerden, Aalaa Alrahman Sherif ... Daron M. Standley
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Inadequate
    1. Neuroscience

    Prior information enhances tactile representation in primary somatosensory cortex

    Pegah Kassraian, Finn Rabe ... Nicole Wenderoth
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology
    2. Genetics and Genomics

    Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

    David A Murphy, Eyal Elyashiv ... Guy Sella
    Background selection is shown to be the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes.
    1. Structural Biology and Molecular Biophysics

    Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

    David N Tippett, Colum Breen ... Raimund Dutzler
    The structural and functional characterization of SLC26A6 provides greater understanding of coupled versus uncoupled transport processes for the SLC26 transporter family.