Browse our latest research

Page 578 of 1,753
    1. Developmental Biology
    2. Neuroscience

    Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions

    Miguel Ramirez, Yuliya Badayeva ... Daniel Goldowitz
    An analysis of enhancer activity during mouse cerebellar development provides an invaluable resource for studying gene expression regulation by enhancers in the developing cerebellum and delivers a rich dataset of novel gene-enhancer associations providing a basis for future in-depth studies.
    1. Cancer Biology

    AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

    Seaho Kim, CheukMan C Au ... Paraskevi Giannakakou
    Advanced microscopy techniques reveal unique biological features that distinguish androgen receptor variant 7 (AR-V7) from the canonical AR, including high intranuclear mobility and rapid nuclear import that occurs independently of importin-α/β.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

    Yitong Li, Vijaya Kumar Balakrishnan ... Yongna Xing
    The coupling of the enzyme/structure core to different short linear motifs represents a novel mechanism to diversify and expand the function of signaling proteins.
    1. Cancer Biology
    2. Computational and Systems Biology

    Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

    Zan He, Zijuan Xin ... Hua Zhao
    A single-cell landscape of acral melanoma and the intermolecular regulatory relationships between microenvironments.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia

    Sean Akira Montgomery, Tetsuya Hisanaga ... Frédéric Berger
    Genomic imprinting in the bryophyte Marchantia polymorpha by Polycomb results in maternal dominance of embryonic gene expression.
    1. Structural Biology and Molecular Biophysics

    Automated systematic evaluation of cryo-EM specimens with SmartScope

    Jonathan Bouvette, Qinwen Huang ... Mario J Borgnia
    SmartScope is the first software package designed to streamline, standardize, and fully automate screening of specimens in cryo-electron microscopy, providing real-time remote control of the microscope and access to data through a standard web interface.
    1. Cell Biology
    2. Medicine

    Interleukin-33 regulates the endoplasmic reticulum stress of human myometrium via an influx of calcium during initiation of labor

    Li Chen, Zhenzhen Song ... Guoying Zhang
    IL-33 plays an important role in the initiation of labor by leading to stress of the ER via an influx of calcium ions in human uterine smooth muscle cells.
    1. Neuroscience

    BehaviorDEPOT is a simple, flexible tool for automated behavioral detection based on markerless pose tracking

    Christopher J Gabriel, Zachary Zeidler ... Laura A DeNardo
    BehaviorDEPOT is a general purpose behavior analysis software that will meet the needs of thousands of behavioral neuroscientists who need accurate, flexible open-source software to analyze naturalistic behaviors and align then with neural data.
    1. Evolutionary Biology

    Species-specific chromatin landscape determines how transposable elements shape genome evolution

    Yuheng Huang, Harsh Shukla, Yuh Chwen G Lee
    The ultimate driver for the substantial between-species difference in the success of transposable elements, the widely distributed genetic parasite, may lie in the overall chromatin environment.
    1. Immunology and Inflammation

    Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

    Joseph Wayne M Fowler, Rong Zhang ... William C Sessa
    Detailed biochemical and metabolic analysis of the inflammatory response in human endothelial cells reveals that inflammation directly regulates cholesterol homeostasis.