Browse our latest research

Page 583 of 1,754
    1. Epidemiology and Global Health

    Effects of side-effect risk framing strategies on COVID-19 vaccine intentions: a randomized controlled trial

    Nikkil Sudharsanan, Caterina Favaretti ... Alain Vandormael
    Small changes to the way COVID-19 vaccine side-effect rates are framed and communicated have meaningful impacts on individuals' vaccination intentions.
    1. Computational and Systems Biology

    Focal seizures are organized by feedback between neural activity and ion concentration changes

    Damiano Gentiletti, Marco de Curtis ... Piotr Suffczynski
    Biophysically realistic computational model reveals how inhibitory interneurons initiate paroxysmal discharges and how changes in the ionic concentrations shape electrographic features of human seizures.
    1. Cancer Biology
    2. Cell Biology

    Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

    Qiangqiang Liu, Qian Luo ... Yushan Zhu
    SIAH2 and OTUD5 orchestrate DBC1 ubiquitination and degradation under hypoxic conditions.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

    Ryo Fujisawa, Cristian Polo Rivera, Karim PM Labib
    UBX proteins reduce the ubiquitin threshold of mammalian p97-UFD1-NPL4.
    1. Developmental Biology

    Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

    Qiyan Mao, Achyuth Acharya ... Frank Schnorrer
    In vitro grown human muscle fibers display remarkable self-organisation capacities at the tissue, cellular, and molecular levels that are coordinated by mechanical tension.
    1. Developmental Biology
    2. Genetics and Genomics

    Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans

    Ruhi Patel, Himani Galagali ... Alison R Frand
    A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.
    1. Neuroscience

    Understanding implicit sensorimotor adaptation as a process of proprioceptive re-alignment

    Jonathan S Tsay, Hyosub Kim ... Richard B Ivry
    A new computational model reveals how implicit sensorimotor adaptation is elicited to re-align one's felt and desired hand position.
    1. Neuroscience

    TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

    Wendy Wing Sze Yue, Lin Yuan ... David Julius
    Capsaicin and other vanilloid receptor ligands alter core body temperature by perturbing central thermoregulatory pathways through activation/inhibition of TRPV1 receptors on peripheral sensory nerve fibers.
    1. Computational and Systems Biology

    Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets

    Zhuang Liu, Letian Zhang ... Ning Xu Landén
    A comprehensive microRNA expression and function landscape of human wounds unraveled miRNAs highly relevant to venous ulcer pathology.
    1. Neuroscience

    Flexible and efficient simulation-based inference for models of decision-making

    Jan Boelts, Jan-Matthis Lueckmann ... Jakob H Macke
    A new machine learning method makes it possible to efficiently identify the parameters of cognitive models using Bayesian inference, even when only model simulations are available.