Browse our latest research

Page 595 of 1,755
    1. Genetics and Genomics

    Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes

    Liang-Dar Hwang, Gunn-Helen Moen, David M Evans
    Adopted individuals in large-scale population based cohorts can be leveraged to partition maternal genetic effects into prenatal and postnatal components, helping elucidate the underlying mechanisms behind these associations, and for diseases, yielding important information regarding the optimal timing of interventions.
    1. Epidemiology and Global Health

    Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics

    Irving Cancino-Muñoz, Mariana G López ... Iñaki Comas
    Low-burden does not mean low local transmission, and tailor-made strategies are needed to control TB based on the knowledge of the local transmission dynamics.
    1. Neuroscience

    Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

    Polina Kosillo, Kamran M Ahmed ... Helen S Bateup
    Chronic inhibition of mTORC1 signaling strongly affects the morphology, physiology and output of dopamine neurons leading to impaired dopaminergic function in mice.
    1. Cell Biology
    2. Evolutionary Biology

    Flagellar energy costs across the tree of life

    Paul E Schavemaker, Michael Lynch
    Prokaryotic and eukaryotic flagella follow a common trend in swimming cost-effectiveness, but eukaryotic flagella are too large for cells with prokaryote volumes, yielding insight into flagellar dissimilarity between taxa.
    1. Developmental Biology
    2. Evolutionary Biology

    Lung evolution in vertebrates and the water-to-land transition

    Camila Cupello, Tatsuya Hirasawa ... Paulo M Brito
    The primitive state of vertebrate lungs is unpaired, evolving to be truly paired in the lineage towards the tetrapods, increasing the pulmonary efficiency during the water-to-land transition.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells

    Daniela Ávila-González, Wendy Portillo ... Néstor F Díaz
    Interaction of human embryonic stem cells (hESC) with human amniotic epithelial cells (hAEC) confers hESC a pluripotent potential that resembles the anteriorized epiblast, which is predisposed to form the neural ectoderm.
    1. Microbiology and Infectious Disease

    Process- and product-related impurities in the ChAdOx1 nCov-19 vaccine

    Lea Krutzke, Reinhild Rösler ... Stefan Kochanek
    Analysis of protein content and protein composition of the ChAdOx1 nCov-19 vaccine, but not of the Ad26.COV2.S vaccine, indicated significantly higher than expected levels of host cell proteins (HCPs) and of free viral proteins.
    1. Neuroscience

    β2-subunit alternative splicing stabilizes Cav2.3 Ca2+ channel activity during continuous midbrain dopamine neuron-like activity

    Anita Siller, Nadja T Hofer ... Jörg Striessnig
    Regulation of Cav2.3 Ca2+ channels by membrane-bound β2 subunit splice variants permits long-lasting channel activity even during prolonged and continuous activity in dopamine neurons, with implications for Parkinson's disease pathophysiology.
    1. Computational and Systems Biology
    2. Neuroscience

    The geometry of robustness in spiking neural networks

    Nuno Calaim, Florian A Dehmelt ... Christian K Machens
    Spiking neural networks become robust to various perturbations of their parameters if their voltages are confined to a lower-dimensional subspace, and both dynamics and robustness can be visualised in this voltage subspace.
    1. Ecology

    Life history predicts global population responses to the weather in terrestrial mammals

    John Jackson, Christie Le Coeur, Owen Jones
    In mammals, how populations respond to extremes in the weather is related to their pace of life, with shorter living species having stronger responses than their longer living counterparts.