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Page 594 of 1,755
    1. Cell Biology

    The molecular mechanism of load adaptation by branched actin networks

    Tai-De Li, Peter Bieling ... Daniel A Fletcher
    An actin-based Brownian Ratchet enables branched actin networks to generate pushing forces, while a capping protein-based Brownian Ratchet provides force feedback that enables these networks to adapt their architecture in response to changing loads.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

    Samuel A Kerk, Lin Lin ... Costas A Lyssiotis
    Inhibition of GOT2 drives growth inhibitory reductive stress that can be rescued by electron acceptors in vitro, whereas GOT2 inhibition in endogenous or transplanted tumor models is tolerated without consequence, highlighting the importance of context when studying tumor metabolism.
    1. Medicine
    2. Microbiology and Infectious Disease

    Reconstruction of transmission chains of SARS-CoV-2 amidst multiple outbreaks in a geriatric acute-care hospital: a combined retrospective epidemiological and genomic study

    Mohamed Abbas, Anne Cori ... Stephan Harbarth
    Nosocomial transmission of SARS-Cov-2 in geriatric settings is complex, with different patterns between patients and healthcare workers working in Covid/non-Covid wards that should be taken into account when designing infection control strategies.
    1. Cell Biology
    2. Developmental Biology

    A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis

    Rodrigo Meléndez García, Olivier Haccard ... Odile Bronchain
    Yap interacts with Rif1, a major DNA replication timing factor, and functions as a brake to control the DNA replication program in Xenopus early embryos and post-embryonic stem cells.
    1. Neuroscience

    Exogenous capture accounts for fundamental differences between pro- and antisaccade performance

    Allison T Goldstein, Terrence R Stanford, Emilio Salinas
    The detection of a salient stimulus triggers a stereotypical oculomotor response, an impulse to look toward it, whose timing and strength are largely independent of behavioral significance and top-down control.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

    Fei Chen, Burcu F Darst ... Christopher A Haiman
    A previously developed multi-ancestry polygenic risk score is potentially an effective prostate cancer risk stratification tool across ancestry populations.
    1. Developmental Biology

    Regionally distinct trophoblast regulate barrier function and invasion in the human placenta

    Bryan Marsh, Yan Zhou ... Robert Blelloch
    Single cell RNA-sequencing of distinct regions of the human placenta identifies a smooth chorion-specific cytotrophoblast population responsible for unique functions of the smooth chorion, including acting as a barrier and restricting invasion.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

    Julia M Flynn, Neha Samant ... Daniel NA Bolon
    Comprehensive mutational scanning of the SARS-CoV-2 protease, Mpro, provides functional and structural information to aid in the design of more effective inhibitors against the protease with reduced potential of evolving viral resistance.
    1. Immunology and Inflammation

    A CD4+ T cell reference map delineates subtype-specific adaptation during acute and chronic viral infections

    Massimo Andreatta, Ariel Tjitropranoto ... Santiago J Carmona
    Description of the transcriptional and clonal landscape of virus-specific CD4+ T cells in acute and chronic viral infections, and a new reference map to interpret CD4 T cell diversity across tissues and biological models.
    1. Cell Biology
    2. Immunology and Inflammation

    HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury

    Parker S Woods, Lucas M Kimmig ... Gökhan M Mutlu
    Transcriptomic and bionergetic analysis shows the importance of HIF-1α activation in enabling tissue-resident alveolar macrophages to perform glycolytic metabolism, which prevents their death and attenuates influenza A virus-induced acute lung injury.