An actin-based Brownian Ratchet enables branched actin networks to generate pushing forces, while a capping protein-based Brownian Ratchet provides force feedback that enables these networks to adapt their architecture in response to changing loads.
Inhibition of GOT2 drives growth inhibitory reductive stress that can be rescued by electron acceptors in vitro, whereas GOT2 inhibition in endogenous or transplanted tumor models is tolerated without consequence, highlighting the importance of context when studying tumor metabolism.
Nosocomial transmission of SARS-Cov-2 in geriatric settings is complex, with different patterns between patients and healthcare workers working in Covid/non-Covid wards that should be taken into account when designing infection control strategies.
Yap interacts with Rif1, a major DNA replication timing factor, and functions as a brake to control the DNA replication program in Xenopus early embryos and post-embryonic stem cells.
Allison T Goldstein, Terrence R Stanford, Emilio Salinas
The detection of a salient stimulus triggers a stereotypical oculomotor response, an impulse to look toward it, whose timing and strength are largely independent of behavioral significance and top-down control.
A previously developed multi-ancestry polygenic risk score is potentially an effective prostate cancer risk stratification tool across ancestry populations.
Single cell RNA-sequencing of distinct regions of the human placenta identifies a smooth chorion-specific cytotrophoblast population responsible for unique functions of the smooth chorion, including acting as a barrier and restricting invasion.
Comprehensive mutational scanning of the SARS-CoV-2 protease, Mpro, provides functional and structural information to aid in the design of more effective inhibitors against the protease with reduced potential of evolving viral resistance.
Massimo Andreatta, Ariel Tjitropranoto ... Santiago J Carmona
Description of the transcriptional and clonal landscape of virus-specific CD4+ T cells in acute and chronic viral infections, and a new reference map to interpret CD4 T cell diversity across tissues and biological models.
Transcriptomic and bionergetic analysis shows the importance of HIF-1α activation in enabling tissue-resident alveolar macrophages to perform glycolytic metabolism, which prevents their death and attenuates influenza A virus-induced acute lung injury.