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Aging is associated with stress-induced senescence of adipose stromal cells, leading to impaired adipogenesis, oxidative stress, mitochondrial dysfunction, and insulin resistance, all being alleviated by metformin treatment of adipose stromal cells.

Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.

Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.

Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.

Myogenin promotes centrosome attenuation and establishes the nuclear envelope as the dominant microtubule organization center via the scaffold protein AKAP6, which is required for the recruitment of centrosomal proteins.

The structure of the Mycobacterium smegmatis CIII₂CIV₂ respiratory supercomplex with telacebec (Q203) bound shows how this tuberculosis drug candidate blocks respiration in mycobacteria.

Inducible fate-mapping analysis demonstrates that neither microglia, CD11c⁺ activated microglia nor border-associated macrophages are replenished by bone marrow-derived cells in Alzheimer’s disease.

Relationships of biomarkers with clinical outcome differed between children and adults and the best combinations associated with moderate/severe dengue comprised of six/seven vascular and immune biomarkers.

Cocaine elicits opposing activity changes in D1R vs D2R spiny projection neurons of the nucleus accumbens with much variability, subsequent recruitment of a subset of D1R neurons drives behavioral sensitization.

The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.