Biochemical analysis reveals the entire route of oligosaccharide processing from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), and the enzymes (EDEM2 and EDEM3/1) responsible for endoplasmic reticulum-associated degradation of misfolded glycoproteins.
Hanumanthu BD Prasada Rao, Takeshi Sato ... Akira Shinohara
Cytological analyses combined with in vitro liposome reconstitution reveal that yeast SUN domain protein, Mps3, shows meiosis-specific phosphorylation in the luminal region of the nuclear envelope during meiosis for chromosome motion and nuclear envelope remodelling.
Harold Fernando Gómez, Mathilde Sabine Dumond ... Dagmar Iber
The 3D shape and dynamic organization of epithelial cells are far more complex than previously believed, but can be explained with simple physical principles based on lateral surface energy minimisation.
Nicholas O Burton, Alexandra Willis ... Eric A Miska
Intergenerational adaptations to stress play a critical role in organismal responses to changing environments and are largely lost or erased after one generation.
Precise genetic manipulations demonstrate that a single-neuron class dynamically controls multiple behaviors by engaging different synapses during high- and low-activity states.
Countrywide agent-based simulations with building-level resolution reveal the importance of demographic repartition and population density on epidemic dynamics of respiratory infections.
Chemically modifying the 5´ends of donor DNA improves the efficiency of homology-directed repair and suppresses end-joining reactions, which will facilitate precise gene editing.
A computational framework and analysis of rodent CA1 data reveals that theta oscillations sequentially sweep through the past, present, and future at a spatial scale that varies with the characteristic speed of the animal.
