Dietary nitrate supplementation could effectively prevent irradiation therapy-induced xerostomia for patients with head and neck cancer, providing a novel, safe, and effective way to resolve this issue.
Danika L Hill, Carly E Whyte ... Michelle A Linterman
Antibody production upon vaccination requires antigen-specific T follicular helper cells whose formation can be suppressed by pro-inflammatory cytokine signalling.
Bacterial population can coordinate individuals of different phenotypes by spatial modulation of their run-and-tumble behaviors, resulting in collective group migration with an ordered structure of phenotypes.
A novel mathematical modeling framework for antibiotic-resistant bacteria combining within-host microbiome-pathogen interactions with population-level pathogen epidemiology, demonstrating how antibiotic consumption and ecological competition come together to drive the spread of resistance.
Hongfei Ji, Anthony D Fouad ... Christopher Fang-Yen
Behavioral, optogenetic, and computational modeling analyses show that the roundworm Caenorhabditis elegans uses a relaxation oscillation mechanism to generate rhythmic locomotor patterns.
The coordinate activity of Sec17/SNAP and Sec18/NSF for membrane fusion is not limited to systems with homotypic fusion and vacuole protein sorting (HOPS), the lysosomal/vacuolar tethering, and SNARE assembly complex.