Browse our latest research

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    1. Medicine

    Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis

    Andrea Milzi, Enrico Domenico Lemma ... Mathias Burgmaier
    Assessing plaque biomechanics by optical coherence tomography highlights the importance of the disrupting effects of plaque stress, bringing stress concentrations as the prime movers of plaque rupture back into clinical practice.
    1. Cell Biology
    2. Neuroscience

    The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

    Vladimir Zhemkov, Jonathon A Ditlev ... Ilya Bezprozvanny
    Signaling function of sigma 1 receptor is related to its ability to organize cholesterol-enriched microdomains in the endoplasmic reticulum membrane.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay

    Joshua Batson, Gytis Dudas ... Hanna Retallack
    How large-scale single mosquito metatranscriptomics can define the mosquito’s complex microbiota and its blood meal sources, and contribute critical epidemiological information needed to control vector borne disease transmission, is shown.
    1. Developmental Biology

    A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

    Chao Yi, Tim WGM Spitters ... Christopher L Antos
    Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
    1. Neuroscience

    GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons

    Jenna Nagy, Briana Ebbinghaus ... Raunak Sinha
    Elimination of GABAA receptors from the axon terminals of specific retinal bipolar cell types alters the sensitivity and kinetics of retinal output.
    1. Immunology and Inflammation

    Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population

    Jianpeng Sheng, Qi Chen ... Christiane Ruedl
    Fate mapping analysis shows that not bona fide Langerhans cells but their ‘look-alikes’ dermal Langerhans cell-like cells migrate to the lymph nodes.
    1. Chromosomes and Gene Expression

    Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay

    Hiroaki Tachiwana, Mariko Dacher ... Noriko Saitoh
    A new method using permeabilized cells and recombinant histones enables to analyze histone incorporations at the DNA sequence level.
    1. Neuroscience

    Medical education and distrust modulate the response of insular-cingulate network and ventral striatum in pain diagnosis

    Giada Dirupo, Sabrina Totaro ... Corrado Corradi-Dell'Acqua
    Behavioral and neural data converge in showing that medical experience reduces reactions to others' pain and distrust toward the target affects the processing of his feedback.
    1. Neuroscience

    Robust and distributed neural representation of action values

    Eun Ju Shin, Yunsil Jang ... Min Whan Jung
    Action-value signals previously found in many brain areas can be accounted for neither by concurrent serial correlations in neural activity and action value nor by signals for other decision variables.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CRISPR-based functional genomics in human dendritic cells

    Marco Jost, Amy N Jacobson ... Jonathan S Weissman
    A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.