Browse our latest research

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    1. Immunology and Inflammation

    Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

    Marie Ghraichy, Valentin von Niederhäusern ... Johannes Trück
    IgH repertoires of physically sorted and bioinformatically selected B cell subpopulations overlap and are characterised by distinct repertoire characteristics, while certain repertoire features correlate with the position of the constant region on the IgH locus.
    1. Neuroscience

    Fast and accurate annotation of acoustic signals with deep neural networks

    Elsa Steinfath, Adrian Palacios-Muñoz ... Jan Clemens
    DAS is a universal tool for segmenting and identifying acoustic signals in single and multi channel recordings robustly, reliably, and at low latency.
    1. Neuroscience

    All-trans retinoic acid induces synaptopodin-dependent metaplasticity in mouse dentate granule cells

    Maximilian Lenz, Amelie Eichler ... Andreas Vlachos
    All-trans retinoic acid increases the number of excitatory synapses in the dorsal hippocampus of mice and improves the ability of neurons to express synaptopodin-dependent synaptic plasticity.
    1. Neuroscience

    Neuronal activity in dorsal anterior cingulate cortex during economic choices under variable action costs

    Xinying Cai, Camillo Padoa-Schioppa
    In economic choices under variable action costs, in contrast to the orbitofrontal cortex, dorsal anterior cingulate cortex represents not pre-decision but post-decision variables, thus might inform subsequent actions based on reward and effort associated with the choice outcomes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states

    Simiao Xu, Yangyang Liu ... Ji Miao
    Hepatic TAZ coordinates the differential expression of gluconeogenic genes in the fasted and fed states by inhibiting glucocorticoid receptor.
    1. Neuroscience

    Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish

    Melanie Holmgren, Michael E Ravicz ... Lavinia Sheets
    Mechanically induced injury of zebrafish lateral-line organs shares key features of damage observed in noise-exposed mammalian ears, such as inflammation and synapse loss, yet, unlike mammals, rapidly repairs following damage.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Two different cell-cycle processes determine the timing of cell division in Escherichia coli

    Alexandra Colin, Gabriele Micali ... Sven van Teeffelen
    Chromosome replication and a different inter-division process both contribute to division control during unperturbed growth, but if division is delayed by increasing cell width the inter-division process becomes solely rate-limiting.
    1. Genetics and Genomics

    Sequence features of retrotransposons allow for epigenetic variability

    Kevin R Costello, Amy Leung ... Dustin E Schones
    Variably methylated retrotransposons have an underlying sequence that allows them to escape KAP1-mediated silencing and recruit ZF-CxxC proteins.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A single synonymous nucleotide change impacts the male-killing phenotype of prophage WO gene wmk

    Jessamyn I Perlmutter, Jane E Meyers, Seth R Bordenstein
    An endosymbiont transgene in Drosophila melanogaster exhibits remarkable phenotypic sensitivity, including to synonymous codon changes.
    1. Developmental Biology
    2. Genetics and Genomics

    Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

    Scott A Rankin, Jeffrey D Steimle ... Aaron M Zorn
    Epistatic analysis in Xenopus and mouse embryos reveals an evolutionarily conserved gene regulatory network downstream of the transcription factor Tbx5 and retinoic acid that coordinates cardiac and pulmonary development.