Alexander Fengler, Lakshmi N Govindarajan ... Michael J Frank
A novel method and software provides researchers with the capability to rapidly, flexibly, and robustly perform Bayesian parameter estimation of theoretically meaningful models in cognitive neuroscience that were heretofore intractable.
The expression of the major circadian component CLOCK is a key regulator of stemness in breast cancer cells, which can be a novel strategy for breast cancer treatment.
Anti-asprosin monoclonal antibodies, a promising pharmacotherapy for the treatment of metabolic syndrome-associated hyperglycemia, obesity, and dyslipidemia.
Stephan Wilmes, Polly-Anne Jeffrey ... Ignacio Moraga
IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
Monica L Fernández-Quintero, Yousra El Ghaleb ... Bernhard E Flucher
Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the CaV1.1 calcium channel.
A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.
Tra Thi Huong Dinh, Hiroyoshi Iseki ... Fumihiro Sugiyama
Mouse genetic manipulations reveal that Cables2 is involved in the progress of gastrulation by interacting with Wnt/β-catenin and the p53 pathways in diminished Rps21 expression.
