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Mouse genetic manipulations reveal that Cables2 is involved in the progress of gastrulation by interacting with Wnt/β-catenin and the p53 pathways in diminished Rps21 expression.

An analysis of recent literature advances novel hypotheses and suggests new experimental approaches in order to build an integrated understanding of prefrontal neural architecture and behavioral repertoires during development.

Identified as a binding factor of transcription factor MYRF, the LRR-TM protein PAN-1 promotes the cell-membrane localization and nuclear translocation of MYRF, which drives synaptic rewiring in Caenorhabditis elegans.

Cryo-EM structures reveal that the conserved CM1 motif drives γTuRC assembly by bridging adjacent γTuSC.

During mouse preimplantation development, the complete loss of actomyosin contractility abolishes cytokinesis but not apico-basal polarisation, lineage specification, or fluid accumulation, which are the critical steps to the formation of the blastocyst.

Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.

Being fast, memory efficient, easy to use, and with powerful integrated tools, TRex will lower barriers of entry into, and enable more ambitious approaches to, the quantitative study of behavior.

Response inhibition is initiated by the right inferior frontal gyrus (rIFG), and stopping performance is predicted by beta-band power as well as beta-band connectivity between rIFG and pre-supplementary motor area.

mRNA profiling alone provides an incomplete picture of molecular aging and examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.

Modulation of cytoplasmic lipopolysaccharide levels sensitises bacteria to polymyxin antibiotics, revealing a novel combination therapeutic approach.