Browse our latest research

Page 961 of 1,744
    1. Biochemistry and Chemical Biology

    How to measure and evaluate binding affinities

    Inga Jarmoskaite, Ishraq AlSadhan ... Daniel Herschlag
    Simple guidelines and a checklist are provided for performing high-quality equilibrium binding measurements.
    1. Developmental Biology
    2. Neuroscience

    The role of the NMD factor UPF3B in olfactory sensory neurons

    Kun Tan, Samantha H Jones ... Miles F Wilkinson
    The nonsense-mediated RNA decay (NMD) branch-specific factor UPF3B influences olfactory sensory neuron cell populations, the olfactory receptor repertoire, and antimicrobial gene expression.
    1. Epidemiology and Global Health

    Early analysis of the Australian COVID-19 epidemic

    David J Price, Freya M Shearer ... James M McCaw
    An analysis of Australian case data demonstrates how the combined strategy of border measures, case targeted interventions, and social distancing effectively contained the first epidemic wave of COVID-19.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Transient intracellular acidification regulates the core transcriptional heat shock response

    Catherine G Triandafillou, Christopher D Katanski ... D Allan Drummond
    When translation stops, cells require intracellular acidification to turn on the conserved heat shock response during stress, and stress-triggered acidification (common in eukaryotes) is adaptive, promoting cell and population fitness.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

    CM Schooling, JV Zhao ... GM Leung
    Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
    1. Neuroscience

    Altered functional connectivity during speech perception in congenital amusia

    Kyle Jasmin, Frederic Dick ... Adam Taylor Tierney
    Individuals with amusia, who have unreliable pitch processing, show decreased functional connectivity between right auditory and left language-related cortex during speech perception, demonstrating a neural basis for compensatory dimensional weighting.
    1. Cell Biology

    Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

    Vasyl Ivashov, Johannes Zimmer ... David Teis
    Metabolic cues enlist ubiquitin ligase adaptors for the selective control of cellular nutrient acquisition strategies.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of VASH1-SVBP bound to microtubules

    Faxiang Li, Yang Li ... Hongtao Yu
    Cryo-electron microscopy structure of vasohibin 1 bound to microtubules reveals how this enzyme prefers to remove the C-terminal tyrosine of α-tubulin in the microtubule lattice.
    1. Chromosomes and Gene Expression

    The nucleosome DNA entry-exit site is important for transcription termination and prevention of pervasive transcription

    A Elizabeth Hildreth, Mitchell A Ellison ... Karen M Arndt
    Disruption of the nucleosome DNA entry-exit site causes readthrough transcription of terminators, decreased nucleosome occupancy, and pervasive noncoding transcription, demonstrating this nucleosomal region protects the genome against inappropriate transcription.
    1. Neuroscience

    A theory of joint attractor dynamics in the hippocampus and the entorhinal cortex accounts for artificial remapping and grid cell field-to-field variability

    Haggai Agmon, Yoram Burak
    A theory of coordinated neural network dynamics in multiple brain areas offers an explanation for several recent experimental findings in the hippocampus and medial entorhinal cortex.