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Electrophysiological analysis and imaging in live zebrafish reveal that infant- and adult-onset SCA13 mutations have distinct effects on the electrical activity, development, and survival of cerebellar Purkinje cells.

Actinonin kills malaria parasites by targeting the apicoplast-associated metalloprotease FTSH1.

A nightshade family gene cluster creates phenotypic novelty in trichome defensive metabolites via evolution of lipid metabolic enzymes.

DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.

Climate change and land-use intensification have negative but largely independent effects on soil animal biomass.

At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.

Analysis of yellow fever burden in Africa illustrates the need to consider the effect of a changing climactic conditions when planning future intervention strategies.

Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.

LocoMouse analysis of severely ataxic reeler mutant mice reveals fundamental features of locomotor ataxia and provides a roadmap for linking high-dimensional behavioral phenotyping to alterations in underlying neural circuits.

Metabolic health and longevity can be separated by ovariectomy, which also protects female mice lacking hepatic mTORC2 from midlife mortality.