Improved nitroreductase variants, optimized prodrugs, and careful experimental design enable scalable, precise cell ablation across model systems for disease modeling, regeneration studies, and high-throughput discovery.
Chiara Bulgarelli, Anna Blasi ... The BRIGHT Study Team
In Gambian infants, positive growth from 0 to 5 months of age predicted more mature brain networks, which in turn predicted cognitive outcomes at 3-5 years.
Transcriptome-wide profiling of bacterial RNA pseudouridylation maps modification landscapes and nominates candidate regulatory sites, offering a resource and foundation for future mechanistic studies of Ψ function in bacteria.
Valentin Mihai Dospinescu, Alexander Mascarenhas ... Nicholas Dale
Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.