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Page 98 of 1,873
    1. Developmental Biology

    Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans

    Zhimin Xu, Xiaoting Feng ... Yingchuan B Qi
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Precision cutaneous stimulation in freely moving mice

    Isobel Parkes, Ara Schorscher-Petcu ... Liam E Browne
    A closed-loop system delivers cutaneous optical stimulation during movement in freely behaving mice, enabling controlled somatosensory input in naturalistic settings.
    1. Cell Biology
    2. Evolutionary Biology

    Amino acid homorepeats act as buffers to maintain proteostasis and constrain the compatible sequence space of proteomes

    Yukihiro Murase, Naoki Kitamura ... Hisao Moriya
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

    Luke J Dillard, Gina Calabrese ... Charles Farber
    Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles in the development of osteoporosis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek D Bansal, Maia Kinnebrew ... Diwakar Shukla
    Multiple competing hypotheses concerning the cholesterol accessibility of oncoprotein Smoothened are quantitatively assessed and experimentally validated, showing that cholesterol takes two pathways from either membrane leaflet to the binding sites.
    1. Developmental Biology
    2. Genetics and Genomics

    A genome-wide MAGIC kit for recombinase-independent mosaic analysis in Drosophila

    Yifan Shen, Ann T Yeung ... Chun Han
    A comprehensive toolkit enables genome-wide, recombinase-independent mosaic analysis in Drosophila, permitting clonal analysis of pericentromeric genes, deficiency chromosomes, and interspecific hybrids previously inaccessible to standard methods.
    1. Developmental Biology

    Mouse germline cysts contain a fusome-like structure that mediates oocyte development

    Madhulika Pathak, Allan C Spradling
    Mammalian oocytes utilize a conserved combination of cell cycle control, cytoskeletal organization, and polarity pathways that are fundamentally shared with other vertebrates and invertebrates.
    1. Neuroscience
    2. Computational and Systems Biology

    Miniscope Processing Suite (MPS): An Intuitive, No-Code, Scalable Pipeline for Long-Duration Calcium Imaging

    Ari Peden-Asarch, Meredith Weinstock ... John F Neumaier
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a GABAergic circuitry

    Lixia Chen, Danya Tian ... Luoying Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation

    Sofie S Jacobsen, Allison B Morehouse ... Celia Kjaerby
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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