Stimulus-receptivity loss increases coupling of a sensory neuron to a second sensory circuit by upregulating neuropeptide receptors, enhancing output of the second circuit, and providing a mechanism for cross-modal plasticity.
The regulatory subunit of protein kinase A (PKA) can both activate and suppress the PKA activity at the plasma membrane, with its graded membrane localization capable of inducing a switch in cell migration.
Michael Chong, Pedrum Mohammadi-Shemirani ... Guillaume Paré
An ethnically robust pipeline for inferring mitochondrial DNA copy number from genotyping arrays was developed and applied to the UKBiobank, elucidating several common and rare loci in genes involved in the synthesis, maintenance, and organization of mitochondrial DNA.
Jana Narasimhan, Suzanne Letinski ... Arthur Branstrom
Novel small molecule inhibitors act against Neisseria including multi-drug resistant isolates by uniquely targeting RNR thereby enabling single pathogen therapy whilst sparing the microbiome.
Simulations of a detailed network model show that the pattern of synaptic interactions resulting from learning is critical for the emergence of population bursts, sequential neuronal activity, and fast oscillations in the hippocampus.
Nithin Sam Ravi, Beeke Wienert ... Kumarasamypet M Mohankumar
Adenine and cytosine base editing of highly homologous HBG proximal promoter identifies novel target sites that result in adult to fetal globin switching without causing 4.9 kb large deletions.
Nicolai Tidemand Johansen, Marta Bonaccorsi ... Lise Arleth
The Mg2+-channel CorA explores a wide conformational landscape of non-conducting states irrespective of bound Mg2+, but only in abscence of Mg2+, conducting states become accessible due to increased backbone dynamics.
Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.
Perceptual haptic representation of materials emerges from unsupervised learning as a consequence of efficient encoding of the physical signals at the input of tactile sensory system.
