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Cell-type-specific circuit analysis reveals a highly polysynaptic pattern of excitatory feedforward connections along the somatosensory-to-motor loop, from cuneate via VPL thalamus to S1 and M1 cortex and corticospinal neurons.

Statistical analysis and LASSO regression modeling provide insights into pathogen-specific host response patterns in cerebrospinal fluid from different disease etiologies to support future classification of pathogen type based on host response patterns in meningitis.

Insulin-like growth factor-1 activates the prefrontal cortex and improves the extinction of aversive memories.

Cryo-EM and chemical cross-linking studies yield an atomic resolution structure of a conserved remodeling machinery in messenger ribonucleoprotein maturation/nuclear export and insights into its coordinated function with a serine–arginine protein.

A machine learning method for action detection is developed and applied toward mouse grooming behavior.

An unbiased mutational screen decodes the molecular basis of phage receptor interactions, identifies key functional regions determining activity and host range, and demonstrates the potential for engineering therapeutic phages.

Endothelial dysfunction due to cardiovascular disease risk factors explained by cardiac endothelial cell transcriptome remodelling.

There is no relationship between the demographic susceptibility to extinction and the estimated extinction chronology among Sahul’s megafauna, suggesting that human choices, a species’ ecological requirements, and/or random climate variation instead determined the extinction chronology.

Minimal genetic modifications of endogenous mosquito genes allow the tissue-specific expression of anti-malarial effectors and convert them into efficient non-autonomous gene drives.

A whole-genome genetic screen links new aspects of oocyte maturation to proteostasis renewal in the immortal Caenorhabditis elegans germ-cell lineage and reveals similarities to somatic cell maintenance during aging.