Various types of stress reset heritable small RNA responses through the function of the p38 MAPK pathway, the transcription factor SKN-1/Nrf2, and the MET-2/SETDB1 putative histone methyltransferase.
Nicholas J Everetts, Melanie I Worley ... Iswar K Hariharan
A single-cell atlas of the developing Drosophila wing disc at two time points enables a detailed understanding of the signals exchanged between different cell populations during development.
3D reconstruction for an insect provides new internal structures at nanometer resolution, and the reconstructed feeding insect reveals unexpected contraction of stylet protractors and suggested a novel phloem sap-sucking model.
Rafael Renteria, Christian Cazares ... Christina M Gremel
Chronic alcohol exposure results in a long-lasting, enhanced endocannabinoid signalling at orbitostriatal synapses that is expressed in a projection-, synapse-, and behaviorally computation-specific manner.
Neuropeptide tachykinin signaling acts as master regulator of behavioral specialization in honeybees by differentially modulating worker responsiveness to task-specific stimuli.
The human brain maintains a representation of latent task states within frontoparietal networks during the generalization of behaviors to novel settings.
Network topology and gene expression patterns in small cell lung cancer reveal two mutually opposing teams of regulators that enable multistability and consequent non-genetic heterogeneity, a clinically unsolved challenge.
Parathyroid hormone attenuates osteoarthritis pain and joint degeneration by modification of subchondral bone remodeling and could be a potential disease-modifying therapy for osteoarthritis.
Bassam Tawfik, Joana S Martins ... Jakob Balslev Sørensen
Synaptotagmin-7 acts synergistically with synaptotagmin-1 by placing vesicles close to the plasma membrane within reach of the SNARE/Munc13-complex, supporting their priming and setting the stage for fast and slow fusion.
