Browse our Research Articles

The role of an important gating domain in linkage between the benzodiazepine drug-binding site and the pore gate in GABA_A receptors.

Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).

A neural circuit between the prefrontal cortex and bed nucleus of the stria terminalis is shown to limit fear to cues that only partially associate with threat.

The evolutionary transition of the agricultural pest Drosophila suzukii to egg laying on ripe fruits was paralleled with several gustatory innovations.

Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.

Kibra-mediated Hippo complex assembly promotes Kibra degradation in a negative feedback loop that is regulated by mechanical tension.

The closest living relatives of animals, the choanoflagellates, switch from a flagellate to an amoeboid phenotype under confinement.

Alterations to brain network communication leading to a progressive loss in descending inhibitory modulation of the spinal cord is a key determinate of pain state development following peripheral nerve injury.

In parallel to protein-driven processes, characteristic physicochemical properties of the endoplasmic reticulum membrane modulate intracellular fat accumulation and lipid droplet formation.

Mechanochemical defects of a β-cardiac myosin mutation that results in severe hypertrophic cardiomyopathy are reported and the heart failure drug omecamtiv mecarbil rescues these defects.