Cancer Biology

Latest articles

1. 1. Immunology and Inflammation
   2. Cancer Biology

   A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets

   Akashdip Singh, Alberto Miranda Bedate ... Linde Meyaard
2. 1. Cell Biology
   2. Cancer Biology

   Automated workflow for the cell cycle analysis of (non-)adherent cells using a machine learning approach

   Kourosh Hayatigolkhatmi, Chiara Soriani ... Simona Rodighiero
3. 1. Cancer Biology

   ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

   Jordina Rincon-Torroella, Marco Dal Molin ... Surojit Sur
4. 1. Cancer Biology
   2. Genetics and Genomics

   Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

   Joakim W Karlsson, Vasu R Sah ... Jonas A Nilsson

   Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
5. 1. Cancer Biology
   2. Neuroscience

   Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

   Jeffrey Barr, Austin Walz ... Paola D Vermeer

   Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
6. 1. Cancer Biology

   PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

   Samarjit Jana, Mainak Mondal ... Kumaravel Somasundaram

   PITAR interaction with TRIM28 mRNA, which encodes a p53 targeting E3 ubiquitin ligase, keeps p53 levels low for cancer cells to divide and attenuates the DNA damage response by p53.
7. 1. Cancer Biology

   Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

   Anne Fajac, Iva Simeonova ... Franck Toledo

   The male-specific tumor-suppressive effects of minor p53 isoforms were correlated with higher Ackr4 expression levels, which have implications for sex-specific cancer prognosis in humans.
8. 1. Cancer Biology
   2. Structural Biology and Molecular Biophysics

   Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

   Gabriella O Estevam, Edmond M Linossi ... James S Fraser

   Deep mutational scanning reveals interactions in the MET kinase domain that are critical for regulation and cancer-related signaling.
9. 1. Cancer Biology

   Engineering PEG10-assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

   Ruijing Tang, Luobin Guo ... Xiaolong Liu

   ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
10. 1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

    Alison G Barber, Cynthia M Quintero ... Tannishtha Reya