Cancer Biology

Latest articles

1. 1. Cancer Biology

   Inhibition of ULK1/2 and KRAS^G12C controls tumor growth in preclinical models of lung cancer

   Phaedra C. Ghazi, Kayla T. O’Toole ... Martin McMahon
2. 1. Cancer Biology

   Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

   Kyle Spinler, Michael Hamilton ... Tannishtha Reya
3. 1. Cancer Biology
   2. Cell Biology

   mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3^IBTK-mediated ubiquitination of eIF4A1 in cancer cells

   Dongyue Jiao, Huiru Sun ... Kun Gao

   Overexpression of inhibitor of Bruton's tyrosine kinase contributes to the process of tumorigenesis by amplifying translation, represents a promising target for anti-cancer therapies.
4. 1. Cancer Biology

   Replication of null results: Absence of evidence or evidence of absence?

   Samuel Pawel, Rachel Heyard ... Leonhard Held

   Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.
5. 1. Cancer Biology
   2. Evolutionary Biology

   High-density sampling reveals volume growth in human tumours

   Arman Angaji, Michel Owusu ... Johannes Berg
6. 1. Cancer Biology

   Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

   Yiwei Huang, Lin Cheng ... Shanye Yin
7. 1. Cancer Biology
   2. Cell Biology

   CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

   Savvas Nikolaou, Amelie Juin ... Laura M Machesky
8. 1. Cancer Biology

   Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

   Keene L. Abbott, Ahmed Ali ... Matthew G. Vander Heiden
9. 1. Medicine
   2. Cancer Biology

   Metabolic heterogeneity of colorectal cancer as a prognostic factor: insights gained from fluorescence lifetime imaging

   Anastasia D Komarova, Snezhana D Sinyushkina ... Marina V Shirmanova
10. 1. Cancer Biology
    2. Cell Biology

    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

    Timothy J Walker, Eduardo Reyes-Alvarez ... Lois M Mulligan

    TMEM127 depletion alters membrane dynamics, promoting cell surface accumulation and constitutive activity of growth factor receptors, and ultimately providing a novel paradigm for oncogenesis through aberrant receptor localization and signaling.