Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Dylan A Valencia, Angela N Koeberlein ... Margot E Quinlan
Complementary biochemical and cell-biological approaches reveal that formin FHOD3-mediated actin elongation, rather than nucleation, is critical for maintaining cardiomyocyte sarcomeres.
A simple mathematical model, incorporating reversible deactivation of β-cells, can potentially explain the rapid onset and remission of a diabetes subtype, ketosis-prone diabetes.
Interferon-γ and prostaglandin E2 signaling oppose each other to determine the balance between two distinct TNF-induced inflammatory gene expression programs relevant for rheumatoid and immune checkpoint inhibitor-induced arthritis.
Sakura is expressed in female germlines, interacts with Otu, and is crucial for germline stem cell renewal and differentiation and oogenesis in Drosophila.
Dysregulated myelopoiesis is identified as a driver of nutritionally acquired immunodeficiency that persists after refeeding and nutritional recovery, indicating exposure to food scarcity may be an immunologic risk factor.
EPHA4 pathway dysfunction causes axon pathfinding defects, resulting in impaired coordinated left-right locomotion by disrupting neural patterning and the function of central pattern generators, thereby potentially leading to idiopathic scoliosis.
Elliot Howard-Spink, Tetsuro Matsuzawa ... Dora Biro
Long-term standardized data collection on wild western chimpanzees reveals late-life changes in stone tool use, and the extent of these changes varies between individuals.
Joseph M Barnby, Jen Nguyen ... London Personality and Mood Disorders Consortium
Individuals with borderline personality disorder maintain rigid, distinct self-other representations, disrupting the bidirectional generalisation that underpins adaptive social learning and interpersonal trust.
