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    1. Neuroscience

    Science Forum: How failure to falsify in high-volume science contributes to the replication crisis

    Sarah M Rajtmajer, Timothy M Errington, Frank G Hillary
    An increased emphasis on falsification – the direct testing of strong hypotheses – will lead to faster progress in science by allowing well-specified hypotheses to be eliminated.
    1. Cancer Biology

    Androgen Receptor: How splicing confers treatment resistance in prostate cancer

    Prathyusha Konda, Srinivas R Viswanathan
    A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.
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    1. Medicine

    Gaucher Disease: Microglia orchestrate neuroinflammation

    Ricardo A Feldman
    Experiments in genetically altered mice reveal that microglia play an important role in the neurological damage associated with neuro-nopathic Gaucher disease.
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  1. A raised fist holding a green spark on a pink and purple background

    Reproductive Rights: Having an abortion during your PhD

    Amanda Smythers
    A graduate student reflects on her choice to end a pregnancy, and on what the overturning of Roe v. Wade means for trainees in the United States.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Development: Shining a light on hematopoietic stem cells

    Anne Schmidt
    A combination of light and electron microscopy has revealed further details about the location and interactions of hematopoietic stem and progenitor cells.
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    1. Computational and Systems Biology
    2. Ecology

    Fermentation: Teaming up to make kombucha

    Olga Ponomarova
    Reducing the microbial diversity in a type of fermented tea reveals the core metabolic interactions responsible for the drink’s signature taste and characteristics.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution: Poor eyesight reveals a new vision gene

    Tathagata Biswas, Jaya Krishnan, Nicolas Rohner
    Comparing the genomes of mammals which evolved to have poor vision identifies an important gene for eyesight.
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    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Adaptive Immunity: Maintaining naivety of T cells

    Ken Duffy
    Mathematical models encoding biological hypotheses reveal new insight into the dynamics of naive immune cells in mice from birth to old age.
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    1. Ecology
    2. Evolutionary Biology
    Silhouette of a rhesus macaque on a yellow/orange background.

    The Natural History of Model Organisms: The rhesus macaque as a success story of the Anthropocene

    Eve B Cooper, Lauren JN Brent ... James P Higham
    The rhesus macaque is a non-human primate that is widely used as a model organism in ecology, evolutionary biology and behavioural science.
    1. Neuroscience

    Brain: Connecting the lines after a stroke

    S Thomas Carmichael
    In mice, stimulating cortical areas in the undamaged hemisphere of a brain affected by stroke impairs recovery.
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