A high-throughput phenotypic human sperm screening platform was developed which allows for major drug discovery programmes for male contraception.

The speed of replisomes in Escherichia coli depends on temperature and varies along the genome in a wave-like manner, with implications for bacterial physiology.

CRISPR/Cas9 genome-wide screens using sterol-sensitive endogenous HMG-CoA reductase (HMGCR) reporter identify the sterol-responsive RNF145 and gp78 as independently responsible for sterol-accelerated degradation of HMGCR, the rate-limiting enzyme of cholesterol biosynthesis.

Remaining focused on the topic at hand when speaking depends on effective selection of task-relevant semantic knowledge, and declines in this ability account for increases in off-topic speech in older people.

DNA concentration, cyclin levels, phosphatase activity, and CDK phosphorylation combine to directly link cell size to cell division.

Ultra-high field neuroimaging dissects the ventral medial geniculate body (vMGB) of the primary auditory pathway from other MGB subregions and reveals that vMGB top-down modulation is relevant for speech recognition.

The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.

Allelic MLA immune receptors have an exceptional propensity to directly detect sequence-unrelated pathogen effectors and this feature might have facilitated functional diversification of the receptor in the host population.

The CAF1 complex binds single histone H3-H4 dimers, and two such complexes associate with extended DNA elements to ensure the deposition of H3-H4 tetramers, the first step in the assembly of nucleosomes.

Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.