TET methylcytosine oxidases cooperate with B lineage-specific transcription factors to promote immunoglobulin gene rearrangement by depositing 5hmC, facilitating DNA demethylation and increasing chromatin accessibility at enhancers.

5-Hydroxymethylcytosine-mediated active DNA demethylation occurs in postmitotic neurons, and is required for their terminal differentiation and function.

Structure-based virtual screening reveals multiple novel TRPV5 inhibitors that bind and exert their effect from previously unidentified binding sites as characterized by cryo-electron microscopy and electrophysiology.

The epigenetic regulator TET1 is regulated by the nutrient-sensing enzyme OGT in vitro and in cells.

Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.

Vitamin C supports the differentiation of antibody-secreting cells by remodeling the DNA methylome to enhance STAT3 DNA binding.

Fam60a, a component of the Sin3a complex, is required for embryonic development and regulates methylation at a subset of gene promoters.

A c-Myc-transcribed long noncoding RNA namely LAST (LncRNA-assisted stabilization of transcripts) collaborates with a cellular factor CNBP to promote the stability of CCND1/cyclin D1 mRNA post-transcriptionally, ensuring the proper G1/Sphase transition of the cell cycle.

Biochemical, molecular, and genetic analyses show that in Drosophila the epigenetic enzyme TET does not demethylate 6mA, which is scarce in the genome, but rather acts in a catalytic-independent manner.

A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.